François-Laurent D. W.
- Country
- Belgium
- Department
- UPC KU Leuven campus Gasthuisberg
Research Overview
- Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide/Quinidine Sulfate) in Treating Agitation in Alzheimer's Dementia Patients
- Evaluation of KarXT Efficacy and Safety in Treating Psychosis Associated with Alzheimer's Disease: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 3 of 45 partner sites.
Specializations
Oncology and Solid Tumors
This investigator is active in a broad oncology portfolio spanning breast cancer, non-small cell lung cancer, colorectal cancer, ovarian cancer, gastric cancer, and other advanced solid malignancies, with interest in both metastatic disease and tumor-specific molecular subtypes.
- Breast cancer
- Non-small cell lung cancer
- Ovarian cancer
- Colorectal cancer
- Urothelial carcinoma
Therapeutic interests include targeted therapy, antibody-drug conjugates, immunotherapy, and treatment strategies for advanced solid tumors across thoracic, gastrointestinal, genitourinary, and gynecologic cancers.
Gastroenterology and Hepatology
Clinical research activity includes inflammatory bowel disease, especially Crohn’s disease and ulcerative colitis, together with gastroesophageal reflux disease, functional dyspepsia, eosinophilic esophagitis, and other digestive disorders.
- Crohn’s disease
- Ulcerative colitis
- Gastroesophageal reflux disease
- Eosinophilic esophagitis
- Functional dyspepsia
Additional therapeutic focus extends to liver disease, including non-alcoholic steatohepatitis, cirrhosis, and cholestatic liver disorders, reflecting interest in chronic inflammatory and metabolic gastrointestinal conditions.
Neurology and Neurodegenerative Disease
The investigator is involved in studies of amyotrophic lateral sclerosis, Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, and other neurodegenerative diseases, as well as selected epileptic and developmental disorders.
- Amyotrophic lateral sclerosis
- Alzheimer’s disease
- Frontotemporal dementia
- Parkinson’s disease
- Epilepsy
Therapeutic interest also includes cognitive decline, refractory status epilepticus, and neuromuscular disorders, with attention to disease-modifying approaches in progressive neurological conditions.
Nephrology, Transplantation, and Immune-Mediated Disease
Research involvement covers chronic kidney disease, IgA nephropathy, APOL1-mediated kidney disease, glomerulonephritis, and kidney transplant rejection, alongside broader autoimmune diseases affecting renal and systemic function.
- Chronic kidney disease
- IgA nephropathy
- Kidney transplant rejection
- Lupus nephritis
- Autoimmune diseases
Therapeutic domains include immunomodulation, transplant medicine, and management of proteinuric kidney disease, with interest in preserving organ function and limiting immune-mediated injury.
Respiratory, Cardiovascular, and Systemic Inflammatory Disorders
The investigator also participates in research on chronic obstructive pulmonary disease, bronchiectasis, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and cardiovascular disease, including atrial fibrillation and heart failure.
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
- Pulmonary arterial hypertension
- Atrial fibrillation
- Heart failure
Other areas of interest include systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and hidradenitis suppurativa, indicating engagement with chronic inflammatory and immune-mediated therapeutic domains.
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