Franco R.
- Country
- Italy
- Department
- #40448:Unità di Dermatologia Clinica
Research Overview
- Phase 2 Randomized, Double‑Blind, Placebo‑Controlled Dose‑Finding Study of Subcutaneous SAR445399 in Adults with Moderate to Severe Hidradenitis Suppurativa
- Efficacy and Safety Evaluation of Amlitelimab Monotherapy in Adults with Severe Alopecia Areata: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study
- A phase 3, randomized, double-blind, placebo-controlled, multicenter study with open-label extension to evaluate the efficacy and safety of bimekizumab in study participants with palmoplantar pustulosis
Data & Insights
Has run more than one trial at 12 of 103 partner sites.
Specializations
Oncology
Clinical research in solid tumors includes breast cancer, non-small cell lung cancer, urothelial carcinoma, gastrointestinal malignancies, and gynecologic cancers. The therapeutic landscape also extends to melanoma, hepatocellular carcinoma, and advanced metastatic disease with molecularly defined targets such as HER2, EGFR, FGFR, KRAS, and ROS1.
- Breast cancer and triple-negative breast cancer
- Non-small cell lung cancer and small cell lung cancer
- Urothelial carcinoma and bladder cancer
- Gastrointestinal, hepatobiliary, and pancreatic cancers
- Lymphoma and other hematologic malignancies
Interest also includes hematologic malignancies such as diffuse large B-cell lymphoma, chronic lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma, and multiple myeloma, alongside advanced tumor settings requiring targeted and immuno-oncologic approaches.
Autoimmune and Inflammatory Diseases
Research activity covers systemic lupus erythematosus, lupus nephritis, psoriatic arthritis, rheumatoid arthritis, systemic sclerosis, and Sjögren’s disease. The therapeutic scope also includes immune-mediated conditions such as idiopathic inflammatory myopathies, vasculitis, and eosinophilic disorders.
- Systemic lupus erythematosus and lupus nephritis
- Psoriatic arthritis and rheumatoid arthritis
- Systemic sclerosis and interstitial lung disease
- Idiopathic inflammatory myopathies
- Vasculitis and eosinophilic disease
Additional involvement includes inflammatory bowel disease such as Crohn’s disease and ulcerative colitis, together with broader immune-mediated and autoimmune therapeutic domains.
Neurology and Neurodegeneration
The investigator’s clinical interests include Alzheimer’s disease, mild cognitive impairment, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. Research also spans migraine, epilepsy, and other neurocognitive disorders.
- Alzheimer’s disease and cognitive decline
- Parkinson’s disease and movement disorders
- Multiple sclerosis and progressive demyelinating disease
- Migraine and headache disorders
- Epilepsy and neurodegenerative disease
This area also includes studies in neuropsychiatric symptoms associated with dementia and other chronic neurologic conditions.
Cardiometabolic and Renal Disease
Clinical involvement extends to atherosclerotic cardiovascular disease, heart failure, myocarditis, and cardiomyopathy, with a parallel focus on chronic kidney disease, IgA nephropathy, and renal cell carcinoma. Metabolic research also includes type 2 diabetes, obesity, and dyslipidemia.
- Atherosclerotic cardiovascular disease and prevention
- Heart failure and inflammatory cardiomyopathy
- Chronic kidney disease and IgA nephropathy
- Type 2 diabetes and obesity
- Renal cell carcinoma
Research interests further include prostate cancer-related imaging and cardiorenal therapeutic strategies in complex multisystem disease.
Ophthalmology and Dermatology
As part of Dermatology in Milan, the investigator is involved in studies of atopic dermatitis, alopecia areata, vitiligo, and cutaneous lupus erythematosus. The clinical landscape also includes ophthalmic conditions such as diabetic macular edema, diabetic retinopathy, age-related macular degeneration, and glaucoma.
- Atopic dermatitis and autoimmune skin disease
- Alopecia areata and vitiligo
- Diabetic macular edema and diabetic retinopathy
- Age-related macular degeneration
- Glaucoma and retinal disease
Therapeutic interest also reaches ocular inflammation and chronic cutaneous autoimmune disorders, reflecting a broad skin-and-eye disease portfolio.
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