Francesco Z.
- Country
- Italy
- Department
- UOC Ematologia
Research Overview
- Efficacy of Ziftomenib Combined with Standard of Care Therapy in Patients with Untreated NPM1-Mutated or KMT2A-Rearranged Acute Myeloid Leukemia
- A Phase II Study of Teclistamab Combined with Autologous Lymphocyte Infusion in Relapsed/Refractory Multiple Myeloma
- Phase 2 Study on Epcoritamab Monotherapy or Combined with Lenalidomide for Anthracycline-Ineligible Diffuse Large B-Cell Lymphoma Patients
Data & Insights
Has run more than one trial at 290 of 507 partner sites.
Specializations
Haematologic malignancies
The clinical research profile centres on lymphoid neoplasms and related blood cancers, with active involvement in studies of diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, Hodgkin lymphoma, and multiple myeloma.
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Mantle cell lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma
Research interests include treatment strategies for relapsed and refractory disease, frontline combinations, and consolidation approaches in hematologic oncology.
Autoimmune and immune-mediated disorders
Another major area of interest is immune dysregulation, particularly immune thrombocytopenia, autoimmune hemolytic anemia, and broader autoimmune cytopenias, including conditions linked to CLL and monoclonal B-cell lymphocytosis.
- Immune thrombocytopenia
- Autoimmune hemolytic anemia
- Autoimmune cytopenias
- CLL-associated immune complications
- Peripheral anti-MAG neuropathy
Clinical activity also extends to therapies aimed at restoring platelet control and improving autoimmune blood disorder management.
Cardiovascular and cardiac disease
The investigator is involved in research spanning heart failure, cardiomyopathy, pulmonary arterial hypertension, myocarditis, pericarditis, and cardiac amyloidosis, with attention to both structural and inflammatory cardiac conditions.
- Heart failure with reduced ejection fraction
- Hypertrophic cardiomyopathy
- Transthyretin amyloid cardiomyopathy
- Pulmonary arterial hypertension
- Inflammatory cardiomyopathy
Additional interest is seen in studies addressing ischemic stroke prevention and broader cardiovascular disease.
Pulmonary and infectious diseases
Clinical trial activity includes pulmonary fibrosis, bronchiectasis, severe asthma with eosinophilic phenotype, chronic obstructive pulmonary disease, and pulmonary sarcoidosis, alongside infectious disease studies in COVID-19, candidemia, and invasive candidiasis.
- Progressive pulmonary fibrosis
- Severe eosinophilic asthma
- Chronic obstructive pulmonary disease
- COVID-19
- Invasive fungal infections
This portfolio reflects interest in respiratory disease control and treatment options for serious systemic infections.
Renal, ophthalmic, and oncologic supportive care
Additional research areas include kidney disease such as IgA nephropathy and multiple autoimmune glomerular diseases, as well as neovascular age-related macular degeneration and selected solid tumors including melanoma, basal cell carcinoma, and colorectal cancer.
- IgA nephropathy
- Neovascular age-related macular degeneration
- Melanoma
- Basal cell carcinoma
- Colorectal cancer
These studies broaden the therapeutic scope to renal immunology, ophthalmology, and selected areas of solid tumor oncology.
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