Francesco T.
- Country
- Italy
- Department
- Nefrologia e dialisi
Research Overview
- Phase III Randomized Double‑Blind Placebo‑Controlled Trial of Elecoglipron (AZD5004) on Renal Decline and Mortality in Adults with Chronic Kidney Disease
- Evaluation of XyloCore Efficacy and Safety Compared to Standard Glucose Solutions in Peritoneal Dialysis for End-Stage Kidney Disease Patients
- Evaluation of Baxdrostat and Dapagliflozin on Chronic Kidney Disease Progression in Hypertensive Patients: A Randomized, Double-Blind, Active-Controlled Phase III Trial
Data & Insights
Has run more than one trial at 142 of 443 partner sites.
Specializations
Kidney disease and dialysis
Clinical research activity in nephrology centers on autosomal dominant polycystic kidney disease, immunoglobulin A nephropathy, chronic kidney disease, end-stage kidney disease, and proteinuric kidney disorders, with interest in therapeutic strategies that address renal function decline and long-term kidney preservation.
- Autosomal dominant polycystic kidney disease
- Immunoglobulin A nephropathy
- Chronic kidney disease
- End-stage kidney disease
- Proteinuria
Additional involvement includes renal care in the context of hypertension, non-diabetic chronic kidney disease, and transfusion-related metabolic complications linked to chronic disease management.
Oncology and solid tumors
Therapeutic interest extends across a broad oncology portfolio, including non-small cell lung cancer, colorectal cancer, gastric cancer, head and neck squamous cell carcinoma, melanoma, hepatocellular carcinoma, and pancreatic cancer, with attention to both advanced disease and resectable settings.
- Non-small cell lung cancer
- Colorectal cancer
- Gastric and gastroesophageal junction cancer
- Head and neck squamous cell carcinoma
- Melanoma
Research also includes HER2-directed disease, KRAS-mutant tumors, and other biomarker-defined solid malignancies relevant to modern precision oncology.
Neurology and neurodegenerative disorders
Investigator activity covers multiple sclerosis, Parkinson’s disease, amyotrophic lateral sclerosis, myasthenia gravis, Lewy body dementia psychosis, and epilepsy, reflecting a strong focus on chronic neurologic and immune-mediated conditions.
- Multiple sclerosis
- Parkinson’s disease
- Amyotrophic lateral sclerosis
- Myasthenia gravis
- Refractory partial onset epilepsy
Additional areas include cognitive impairment, autoimmune encephalitis, and other nervous system diseases associated with progressive functional decline.
Autoimmune, inflammatory, and dermatologic disease
Clinical research interests include rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, Sjögren’s syndrome, psoriatic arthritis, atopic dermatitis, hidradenitis suppurativa, and prurigo nodularis.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Sjögren’s syndrome
- Atopic dermatitis
- Hidradenitis suppurativa
Therapeutic scope also includes psoriasis, cutaneous lupus erythematosus, and other immune-mediated skin and connective tissue disorders requiring targeted disease control.
Respiratory, metabolic, and cardiovascular conditions
Research activity further spans asthma, chronic obstructive airway symptoms, type 2 diabetes mellitus, obesity, high cardiovascular risk, myocardial infarction, and atherosclerotic cardiovascular disease, supporting a broad internal medicine profile.
- Asthma
- Type 2 diabetes mellitus
- High cardiovascular risk
- Myocardial infarction
- Atherosclerotic cardiovascular disease
Additional involvement includes migraine, depression, schizophrenia, and selected infectious diseases such as COVID-19 and tuberculosis.
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