Francesco R.
- Country
- France
- Department
- Oncology
Research Overview
- A Randomized, Open-Label, Phase 2/3 Study of Datopotamab Deruxtecan (Dato-DXd) plus Carboplatin or Cisplatin versus Gemcitabine plus Carboplatin or Cisplatin in Participants with Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) who Progressed During or After Enfortumab Vedotin (EV) plus Pembrolizumab Combination Treatment. TROPION-Urothelial03 (TU03).
- Phase III Non-Inferiority Trial of Ribociclib and Endocrine Therapy Versus Chemotherapy Plus Ribociclib in HR+ HER2- Intermediate-Risk Early Breast Cancer
- Thromboprophylaxis in good and intermediate prognosis advanced germ cell tumors (GIG-T)
Data & Insights
Has run more than one trial at 43 of 213 partner sites.
Specializations
Genitourinary Oncology
Clinical research interest in prostate cancer, bladder cancer, and urothelial carcinoma, with attention to both localized and advanced disease settings, including non-muscle-invasive bladder cancer and muscle-invasive bladder cancer.
- High-risk localized or locally advanced prostate cancer
- Metastatic castration-resistant prostate cancer
- High-risk non-muscle-invasive bladder cancer
- Locally advanced or metastatic urothelial carcinoma
Work in this area also includes androgen receptor-directed strategies and intravesical approaches for bladder malignancies.
Breast Cancer and Endocrine Therapy
Active involvement in early breast cancer, triple-negative breast cancer, and ER-positive HER2-negative breast carcinoma, with a focus on recurrence risk, adjuvant treatment, and treatment intensification.
- Triple-negative breast cancer
- ER+/HER2- metastatic breast cancer
- Intermediate-risk HR+ HER2- early breast cancer
- Residual disease after neoadjuvant therapy
Research interest extends to CDK4/6 inhibition, immune-based therapy, and endocrine treatment optimization.
Colorectal Cancer and Gastrointestinal Malignancies
Clinical trial activity includes colon cancer and metastatic oeso-gastric adenocarcinoma, with emphasis on adjuvant treatment, relapse prevention, and therapy selection after surgery.
- High-risk stage III colon cancer
- Colon carcinoma
- ctDNA-guided treatment in colon cancer
- Metastatic oeso-gastric adenocarcinoma
Interest also covers circulating tumor DNA-informed decisions and post-operative systemic therapy.
Thoracic Disease and Supportive Care
Research involvement spans non-small cell lung cancer and chronic obstructive pulmonary disease, alongside symptom-focused care in acute settings.
- Non-small cell lung cancer
- Chronic obstructive pulmonary disease (COPD)
- Migraine
- High-flow oxygen therapy in emergency care
This area reflects interest in both oncology and non-oncologic therapeutic support.
Urologic Procedures and Perioperative Care
Additional clinical interest includes conditions and interventions related to benign prostatic hyperplasia, kidney stone disease, and infection prevention around urologic surgery.
- Benign prostatic hyperplasia
- Destruction of kidney stones
- Urinary tract infection prevention
- Perioperative urologic management
These studies connect procedural care with urology-focused therapeutic optimization.
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