Francesco N.
- Country
- Italy
- Department
- S.C. Cardiologia
Research Overview
Data & Insights
Has run more than one trial at 11 of 15 partner sites.
Specializations
Cardiovascular & Metabolic Medicine
Research emphasizes atherosclerotic cardiovascular disease, heart failure phenotypes, and lipid disorders.
- Heart failure with preserved ejection fraction
- Lipoprotein(a) reduction therapies
- ATTR amyloid cardiomyopathy
- Dyslipidemia at high cardiovascular risk
- MACE prevention strategies
Efforts include trialing novel agents to mitigate cardiovascular events and improve metabolic risk profiles.
Thoracic Oncology
Focus is on malignant diseases of the lung and pleura, especially molecularly defined subtypes.
- KRAS G12C mutated non‑small cell lung cancer
- ALK‑positive NSCLC
- EGFR exon20 insertion NSCLC
- Advanced metastatic lung cancer
- Neoadjuvant strategies for resectable NSCLC
The work integrates targeted therapies and immunotherapy to enhance survival outcomes.
Hematologic Malignancies & Stem Cell Transplantation
Investigations target acute leukemias, chronic lymphoid neoplasms, and transplantation approaches.
- Acute Myeloid Leukemia with NPM1 mutation
- Acute lymphoblastic leukemia
- Chronic lymphocytic leukemia
- Allogeneic peripheral hematopoietic stem cell transplant
- Multiple myeloma eligible for autologous transplant
Clinical studies assess novel agents and combination regimens in relapsed or high‑risk disease.
Infectious Complications in Immunocompromised Patients
Research addresses viral reactivations and opportunistic infections in transplant recipients.
- Cytomegalovirus infection post‑HSCT
- Maribavir therapy for resistant CMV
- Prophylaxis strategies in hematopoietic stem cell transplant
- Management of antiviral drug intolerance
- Safety monitoring of antiviral regimens
The aim is to improve infection control while minimizing toxicity.
Autoimmune & Inflammatory Disorders
Studies include systemic autoimmune diseases and skin inflammation.
- Primary Sjögren's syndrome
- Nummular dermatitis
- Cellular senescence‑driven inflammation
- Therapies targeting inflammatory pathways
- Biomarker‑guided treatment decisions
Investigations explore disease‑modifying agents and patient‑stratified approaches.
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