Francesco D. C.
- Country
- Italy
- Department
- Unità Operativa Radiologia
Research Overview
- Efficacy and Safety of Radioembolization with Cisplatin, Gemcitabine, and Durvalumab in Unresectable Intrahepatic Cholangiocarcinoma
- (21197) A multicenter, randomized, prospective double-blind, cross over Phase 3 study to evaluate the efficacy and safety of 0.04 mmol Gd/kg body weight of gadoquatrane for MRI in adults with known or suspected pathology of any body region (except CNS), compared to 0.1 mmol Gd/kg approved macrocyclic gadolinium-based contrast agents (GBCAs)
- Evaluation of Long-term Effects of Repeated Gadolinium-based Contrast Agents on Motor and Cognitive Functions in Neurologically Normal Adults
Data & Insights
Has run more than one trial at 1 of 57 partner sites.
Specializations
Oncology and Solid Tumors
Francesco De Cobelli is involved in clinical research on a broad spectrum of solid tumors, with a strong emphasis on breast cancer, non-small cell lung cancer, urothelial carcinoma, hepatocellular carcinoma, and gastrointestinal malignancies. His activity also extends to advanced and metastatic disease settings, including tumor types with specific molecular features and treatment resistance patterns.
- Advanced and metastatic solid malignancies
- Breast, lung, bladder, and hepatobiliary cancers
- Biomarker-defined oncology
- Gynecologic and gastrointestinal cancers
His oncology portfolio reflects a particular interest in treatment pathways for difficult-to-manage cancers and in therapeutic strategies that support medical innovation in precision oncology.
Genitourinary and Prostate Cancer Imaging
His research landscape includes a clear focus on prostate cancer, renal cell carcinoma, and bladder cancer, alongside advanced imaging approaches used in urologic oncology. This includes work related to diagnostic assessment and disease characterization in clinically relevant prostate disease and other genitourinary cancers.
- Prostate cancer detection and staging
- Renal cell carcinoma
- Muscle-invasive and non-muscle-invasive bladder cancer
- Advanced urothelial malignancies
These interests place him at the intersection of oncologic management and radiologic evaluation in urologic disease.
Cardiovascular and Metabolic Disease
Francesco De Cobelli is also active in studies addressing atherosclerotic cardiovascular disease, heart failure, cardiomyopathy, myocarditis, type 2 diabetes, and obesity. His research involvement spans prevention, risk reduction, and treatment of cardiometabolic conditions with significant long-term clinical burden.
- Atherosclerotic cardiovascular disease
- Heart failure and inflammatory cardiomyopathy
- Type 2 diabetes and obesity
- Myocarditis-related cardiac disease
This domain highlights therapeutic interest in conditions where cardiovascular risk and metabolic dysfunction overlap.
Autoimmune, Inflammatory, and Renal Disorders
His clinical research also covers autoimmune diseases and immune-mediated inflammatory disorders, including systemic lupus erythematosus, lupus nephritis, Crohn’s disease, ulcerative colitis, psoriatic arthritis, and systemic sclerosis. Renal involvement is represented through IgA nephropathy and other chronic kidney disorders.
- Inflammatory bowel disease
- Systemic autoimmune rheumatic disease
- Immune-mediated kidney disease
- Chronic inflammatory and fibrosing conditions
His therapeutic interests in this area connect immune modulation with organ-specific disease control.
Neurodegenerative and Ophthalmic Conditions
Francesco De Cobelli contributes to research in neurodegenerative disease and ophthalmology, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, migraine, diabetic macular edema, age-related macular degeneration, and glaucoma. His work also includes imaging-related assessment in central nervous system and eye disease.
- Alzheimer’s disease and cognitive decline
- Parkinson’s disease and multiple sclerosis
- Retinal disease and macular degeneration
- Glaucoma and diabetic eye disease
This area shows a therapeutic interest in disorders affecting both visual function and neurological integrity.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.