Florence T.
- Country
- Belgium
- Department
- Oncology
Research Overview
Data & Insights
Has run more than one trial at 19 of 91 partner sites.
Specializations
Breast and Gynecologic Oncology
Florence Troisfontaine is involved in clinical research in breast cancer and gynecologic malignancies, with attention to advanced, recurrent, and high-risk disease settings. The portfolio includes treatment questions in hormone receptor-positive and HER2-defined breast cancer, as well as ovarian, endometrial, cervical, and related pelvic cancers.
- Hormone receptor-positive and HER2-negative breast cancer
- Triple-negative and HER2-positive breast cancer
- Endometrial, ovarian, cervical, and fallopian tube cancers
Her work also extends to molecularly selected tumors, including HER2-low, PIK3CA-mutated, and mismatch repair-deficient disease, reflecting a strong therapeutic focus on precision oncology.
Hematologic Malignancies and Cellular Therapy
Her research landscape includes a substantial focus on hematologic cancers, particularly leukemias and lymphomas that require novel immunologic or transplant-based strategies. This includes studies in acute leukemia, chronic lymphoid disorders, aggressive lymphomas, and myeloproliferative disease.
- Acute lymphoblastic leukemia and acute myeloid leukemia
- Diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma
- Multiple myeloma and myelofibrosis
She is also involved in research linked to allogeneic hematopoietic stem cell transplantation, CAR T-cell therapy, and other advanced immune-based approaches in refractory blood cancers.
Gastrointestinal and Hepatobiliary Disease
Florence Troisfontaine participates in studies across gastrointestinal oncology and inflammatory bowel disease, spanning both malignant and immune-mediated conditions. Her interests include colorectal, gastric, esophageal, pancreatic, biliary tract, and hepatocellular cancers, alongside Crohn’s disease and ulcerative colitis.
- Colorectal, gastric, esophageal, and pancreatic cancers
- Biliary tract and hepatocellular carcinoma
- Crohn’s disease and ulcerative colitis
Her trial activity also touches on postoperative recurrence prevention and targeted therapy in gastrointestinal cancer, as well as biologic treatment strategies in chronic intestinal inflammation.
Thoracic, Genitourinary, and Solid Tumor Therapy
Her clinical research includes a broad range of solid tumors, with recurring involvement in non-small cell lung cancer, small cell lung cancer, and urothelial carcinoma. Additional activity spans prostate cancer, renal cell carcinoma, and other advanced or metastatic solid malignancies.
- Non-small cell lung cancer and small cell lung cancer
- Metastatic prostate cancer and urothelial carcinoma
- Renal cell carcinoma and unresectable solid tumors
She is engaged in research on immunotherapy, antibody-based treatment, and other novel systemic approaches for difficult-to-treat thoracic and genitourinary cancers.
Immune-Mediated, Pulmonary, and Dermatologic Disorders
Her portfolio also includes studies in autoimmune disease, chronic lung disease, and inflammatory skin disorders. These areas include systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis with interstitial lung disease, idiopathic pulmonary fibrosis, asthma, psoriasis, hidradenitis suppurativa, and atopic dermatitis.
- Systemic lupus erythematosus and rheumatoid arthritis
- Idiopathic pulmonary fibrosis and systemic sclerosis-associated interstitial lung disease
- Psoriasis, hidradenitis suppurativa, and atopic dermatitis
Her research interests in this domain reflect a focus on immune modulation, fibrotic lung disease, and chronic inflammatory conditions requiring targeted therapeutic innovation.
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