Flora Z.
- Country
- Greece
- Department
- Oncology Unit, B' Surgery Department National and Kapodistrian UoA
Research Overview
- A Phase 3 Randomized Open-Label Study of Sacituzumab Govitecan Versus Physician's Choice in Recurrent or Persistent Endometrial Cancer Post-Chemotherapy and Immunotherapy
- Efficacy of Cobolimab, Dostarlimab, and Docetaxel in Advanced Non-Small Cell Lung Cancer Post Anti-PD(L)1 Therapy and Chemotherapy
- Evaluation of HLX10 Combined with Chemotherapy and Radiotherapy in Limited-Stage Small Cell Lung Cancer: A Phase III Randomized, Double-Blind Study
Data & Insights
Has run more than one trial at 663 of 998 partner sites.
Specializations
Breast Cancer and Endocrine Therapy
Clinical research in breast cancer includes HR-positive, HER2-negative, HER2-positive, and triple-negative breast cancer, with attention to early-stage, locally advanced, metastatic, and high-risk disease. The therapeutic scope also covers recurrence prevention and treatment after prior endocrine-based therapy.
- Advanced breast cancer
- Early breast cancer
- Triple-negative breast cancer
- HER2-positive breast cancer
- Endocrine-resistant breast cancer
Work in this area reflects a sustained focus on targeted and hormone-directed strategies for disease control and recurrence reduction.
Hematologic Malignancies and Plasma Cell Disorders
Research activity spans multiple myeloma, smoldering multiple myeloma, Waldenström macroglobulinemia, myelodysplastic syndrome, and related B-cell malignancies. The portfolio also includes relapsed and refractory settings, reflecting interest in treatment-resistant blood cancers and marrow-based disorders.
- Multiple myeloma
- Relapsed/refractory myeloma
- Waldenström macroglobulinemia
- Diffuse large B-cell lymphoma
- Myelodysplastic syndrome
The therapeutic emphasis includes novel immunologic and proteasome-targeted approaches in hematologic oncology.
Thoracic, Genitourinary, and Gastrointestinal Oncology
Clinical trials cover non-small cell lung cancer, small cell lung cancer, urothelial carcinoma, renal cell carcinoma, and colorectal cancer. Additional activity includes pancreatic cancer and other solid tumors with actionable molecular features such as KRAS G12C and HER2 alterations.
- Non-small cell lung cancer
- Small cell lung cancer
- Urothelial carcinoma
- Renal cell carcinoma
- Colorectal cancer
This area highlights interest in precision oncology across metastatic and treatment-refractory solid tumors.
Cardiovascular Medicine and Thromboembolic Risk
Research includes heart failure with reduced, preserved, and mildly reduced ejection fraction, myocardial infarction, atrial fibrillation, stroke prevention, and broader atherosclerotic cardiovascular disease. The portfolio also extends to cardiac amyloidosis and inflammatory cardiovascular conditions.
- Heart failure
- Myocardial infarction
- Atrial fibrillation
- Acute ischemic stroke
- Transthyretin amyloid cardiomyopathy
The therapeutic focus includes antithrombotic, anti-inflammatory, and cardiometabolic strategies for high-risk vascular disease.
Amyloidosis, Autoimmune Disease, and Inflammatory Conditions
Investigations include AL amyloidosis, transthyretin amyloidosis, inflammatory bowel disease such as ulcerative colitis and Crohn's disease, sepsis, thrombocytopenia, and pulmonary arterial hypertension. The research landscape also includes selected endocrine and immune-mediated disorders.
- AL amyloidosis
- Transthyretin amyloidosis
- Ulcerative colitis
- Crohn's disease
- Sepsis
These studies point to a therapeutic interest in protein misfolding disorders, immune dysregulation, and systemic inflammation.
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