Flora S.
- Country
- Greece
- Department
- 4th Pathology- Oncology Clinic
Research Overview
- Phase 3 Study of PF-07220060 and Letrozole Versus CDK4/6 Inhibitors and Letrozole in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer
- Phase 3 Study of Sigvotatug Vedotin and Pembrolizumab Versus Pembrolizumab Monotherapy in PD-L1 High Non-Small Cell Lung Cancer
- C4551002 - An Interventional, Open-Label, Randomized, Multicenter, Phase 3 Study of PF-07248144 Plus Fulvestrant Compared to Investigator’s Choice of Therapy in Adult Participants with Hormone Receptor-Positive, HER2-Negative Advanced/Metastatic Breast Cancer Whose Disease Progressed After Prior CDK4/6 Inhibitor-based Therapy
Data & Insights
Has run more than one trial at 65 of 254 partner sites.
Specializations
Cardiovascular Disease and Heart Failure
Flora Stavridi is involved in clinical research focused on atherosclerotic cardiovascular disease, myocardial infarction, atrial fibrillation, hypertension, and a broad spectrum of heart failure conditions, including HFrEF, HFpEF, and HFmrEF. Her trial portfolio also includes populations with systemic inflammation, chronic kidney disease, obesity, and elevated lipoprotein(a).
- Acute myocardial infarction
- Heart failure with preserved or mildly reduced ejection fraction
- Atherosclerotic cardiovascular disease
- Hypertriglyceridemia
- Elevated lipoprotein(a)
Her cardiovascular research activity is centered on prevention of major adverse cardiovascular events, reduction of heart failure burden, and management of cardiometabolic risk.
Breast Cancer and Endocrine Oncology
Her oncology interests include breast cancer across early, locally advanced, recurrent, and metastatic settings, with emphasis on hormone receptor-positive and HER2-negative disease. She is also involved in research for older patients and treatment-resistant disease, reflecting a strong focus on endocrine-based and targeted therapeutic strategies.
- ER+/HER2- early breast cancer
- Advanced/metastatic breast cancer
- Hormone receptor-positive breast cancer
- Older patients with breast cancer
- Locally recurrent inoperable breast cancer
Her work includes studies aimed at improving disease control in endocrine-sensitive and endocrine-resistant breast cancer.
Gynecologic Oncology
Flora Stavridi is active in clinical research covering endometrial cancer, ovarian cancer, fallopian tube cancer, primary peritoneal cancer, and cervical cancer. Her involvement spans recurrent, advanced, platinum-sensitive, and platinum-resistant disease, with attention to both systemic and combined-modality treatment approaches.
- Advanced endometrial cancer
- Platinum-resistant ovarian cancer
- Platinum-sensitive epithelial ovarian cancer
- Locally advanced cervical cancer
- Primary peritoneal cancer
Her gynecologic oncology portfolio reflects a therapeutic interest in difficult-to-treat malignancies with high unmet need.
Head and Neck Cancer and Lung Cancer
Her research also extends to head and neck squamous cell carcinoma and non-small cell lung cancer, including incurable, metastatic, and recurrent disease. This area highlights her involvement in immunotherapy-based and targeted treatment development for advanced solid tumors.
- Metastatic/recurrent head and neck squamous cell carcinoma
- First-line head and neck cancer
- Non-small cell lung cancer
- PD-L1-positive tumors
- Incurable advanced solid tumors
Her trial involvement in this field is aligned with therapeutic innovation in advanced malignancies requiring new systemic options.
Neurology and Cognitive Disorders
Flora Stavridi contributes to clinical research in Alzheimer’s disease, including mild cognitive impairment and mild to moderate dementia. Her interest in this domain includes therapies aimed at preserving cognition and functional independence in neurodegenerative disease.
- Mild cognitive impairment
- Alzheimer’s disease
- Mild dementia
- Cognitive function
- Global functioning
Her neurology-related research adds a distinct therapeutic dimension beyond oncology and cardiovascular medicine.
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