Filipe G. D. C. N.
- Country
- Portugal
- Department
- Gastroenterology Service
Research Overview
Data & Insights
Has run more than one trial at 0 of 9 partner sites.
Specializations
Acute‑on‑Chronic Liver Failure and Decompensated Cirrhosis
The work emphasizes acute-on-chronic liver failure management, exploring organ‑failure dynamics and mortality risk in patients with chronic liver disease.
- Organ failure assessment in ACLF
- Biomarker‑driven risk stratification
- Therapeutic interventions for hepatic decompensation
Clinical efforts aim to reduce short‑term mortality and improve transplant candidacy.
Alpha‑1 Antitrypsin Deficiency‑Associated Liver Disease
Focused investigation targets alpha‑1 antitrypsin deficiency–related hepatic fibrosis and its progression to cirrhosis.
- Antisense therapy evaluation
- Fibrosis biomarkers monitoring
- Impact on liver function and quality of life
Studies seek to modify disease trajectory and delay the need for liver transplantation.
Cardiovascular Thrombosis and Anticoagulation Reversal
Research includes reversal of factor Xa inhibitor anticoagulation in urgent surgical settings and high‑risk atrial fibrillation management.
- Andexanet alfa efficacy in bleeding control
- Safety of rapid anticoagulation reversal
- Outcomes in patients with prior intracranial hemorrhage
Objectives center on balancing thrombotic protection with peri‑procedural bleeding risk.
Pulmonary Arterial Hypertension Therapeutics
The investigator contributes to studies on pulmonary arterial hypertension and novel inhaled agents aimed at improving exercise capacity.
- Seralutinib as adjunctive PAH therapy
- Exercise tolerance endpoints
- Integration with background PAH medications
Efforts target functional improvement and disease progression attenuation.
Immune‑Mediated Dermatologic and Autoimmune Disorders
Clinical focus extends to moderate‑to‑severe atopic dermatitis and systemic autoimmune conditions such as systemic lupus erythematosus.
- Upadacitinib efficacy across dermatologic and rheumatologic indications
- Long‑term safety monitoring
- Biomarker assessment for disease activity
Studies aim to broaden therapeutic options for patients with refractory inflammatory disease.
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