Filipe B.
- Country
- Portugal
- Department
- Rheumatology
Research Overview
- Efficacy and Safety Evaluation of Deucravacitinib in Adults with Active Sjögren's Syndrome: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
- Long-term Safety and Efficacy Assessment of Ianalumab in Sjögren’s Syndrome: A Randomized, Double-blind, Two-arm NEPTUNUS Extension Study
- A Phase 3 Randomized Double-Blind Trial of Risankizumab Versus Placebo in Patients with Active Psoriatic Arthritis and Prior Biologic Therapy Inadequacy
Data & Insights
Has run more than one trial at 99 of 252 partner sites.
Specializations
Autoimmune Rheumatic Diseases
The investigator concentrates on systemic autoimmune conditions such as systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, and Sjögren’s syndrome, addressing both cutaneous and articular manifestations.
- Systemic lupus erythematosus (SLE)
- Rheumatoid arthritis
- Psoriatic arthritis
- Sjögren’s syndrome
- Cutaneous lupus erythematosus
Research spans early‑stage and refractory disease cohorts, emphasizing long‑term safety and disease‑modifying outcomes.
Inflammatory Skin Disorders
Focused on chronic dermatologic inflammation, the work includes atopic dermatitis, plaque psoriasis, hidradenitis suppurativa, alopecia areata, and prurigo nodularis.
- Atopic dermatitis
- Psoriasis
- Hidradenitis suppurativa
- Alopecia areata
- Prurigo nodularis
Efforts target both skin‑limited disease and systemic involvement, integrating biologic and small‑molecule strategies.
Respiratory and Allergic Diseases
Investigations address airway inflammation and allergic pathways, including asthma, chronic obstructive pulmonary disease, and allergic rhinitis with or without concomitant asthma.
- Asthma (severe and uncontrolled)
- Chronic obstructive pulmonary disease (COPD)
- Allergic rhinitis/rhinoconjunctivitis
- Acute bacterial skin and skin‑structure infections
The program emphasizes novel anti‑inflammatory agents and inhaled therapies to improve lung function and symptom control.
Oncology and Targeted Cancer Therapies
Broad oncologic interests cover solid tumours such as breast cancer, non‑small cell lung cancer, head and neck squamous cell carcinoma, as well as haematologic malignancies like diffuse large B‑cell lymphoma.
- Hormone‑receptor positive/HER2‑negative breast cancer
- Advanced/metastatic non‑small cell lung cancer
- Head and neck squamous cell carcinoma
- Diffuse large B‑cell lymphoma
- Melanoma (advanced)
Research integrates targeted agents, immunotherapies, and combination regimens to enhance survival outcomes.
Cardiovascular and Metabolic Disorders
Key interests include structural heart disease and metabolic risk, notably hypertrophic cardiomyopathy and obesity, with attention to symptom burden and functional capacity.
- Symptomatic hypertrophic cardiomyopathy
- Obstructive cardiomyopathy
- Obesity
- Non‑obstructive hypertrophic cardiomyopathy
Efforts focus on disease‑modifying therapies and quality‑of‑life improvements for affected patients.
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