Fernando Manuel H.
- Country
- Spain
- Department
- Medical Oncology
Research Overview
- Study of Inavolisib with Trastuzumab and Pertuzumab as Maintenance Therapy in Patients with HER2‑Positive PIK3CA‑Mutated Locally Advanced or Metastatic Breast Cancer
- Evaluation of ERBB2 mRNA Cut-Point for Predicting Trastuzumab Deruxtecan Efficacy in Advanced or Metastatic Cancer Patients
- Phase 3 Randomized Open-Label Study of OP-1250 Versus Standard of Care in ER+, HER2- Advanced or Metastatic Breast Cancer Post-Endocrine and CDK4/6 Inhibitor Therapy
Data & Insights
Has run more than one trial at 143 of 438 partner sites.
Specializations
Oncology – Advanced Solid Tumors
The investigator concentrates on advanced solid tumors across multiple organ sites, emphasizing molecularly defined subgroups.
- non‑small cell lung cancer
- triple‑negative breast cancer
- metastatic melanoma
- KRAS‑G12C‑mutated cancers
- HER2‑positive breast malignancies
These efforts support targeted therapeutic strategies for patients with high‑risk disease.
Hematology – Lymphoid Malignancies
Research activities include the study of lymphoid cancers with diverse genetic backgrounds.
- diffuse large B‑cell lymphoma
- chronic lymphocytic leukemia
- follicular lymphoma
- mantle‑cell lymphoma
- multiple myeloma relapse
The focus is on novel agents that address refractory disease states.
Cardiovascular & Metabolic Medicine
Investigations target cardiovascular risk reduction and metabolic dysregulation in high‑risk populations.
- atherosclerotic cardiovascular disease
- heart failure with reduced ejection fraction
- atrial fibrillation
- hypercholesterolemia
- elevated lipoprotein(a)
Therapeutic focus includes agents that modify disease progression and event rates.
Renal & Glomerular Disorders
The work encompasses chronic kidney disease and immune‑mediated glomerulopathies.
- IgA nephropathy
- focal segmental glomerulosclerosis
- complement‑mediated kidney disease
- end‑stage renal disease on dialysis
- proteinuric kidney disease
Efforts aim to preserve renal function and reduce proteinuria.
Autoimmune & Inflammatory Diseases
Clinical focus includes immune‑mediated inflammatory conditions affecting joints, gut, and skin.
- rheumatoid arthritis
- psoriatic arthritis
- ulcerative colitis
- Crohn’s disease
- atopic dermatitis
Research seeks to modulate pathogenic pathways and improve disease control.
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