Femke V. V.
- Country
- The Netherlands
- Department
- Oncologie
Research Overview
- Evaluation of Bintrafusp Alfa Combined with Chemoradiation in Esophageal Squamous Cell Carcinoma: A Feasibility Study
- Phase 3 Randomized Study of Adjuvant Pembrolizumab With or Without mRNA-4157 in Resectable Stage II-IIIB (N2) Non-Small Cell Lung Cancer Not Achieving pCR
- Phase 3 Randomized Study of MK-7684A with Etoposide and Platinum vs. Atezolizumab for First-Line Treatment of Extensive-Stage Small Cell Lung Cancer
Data & Insights
Has run more than one trial at 14 of 125 partner sites.
Specializations
Cardiovascular and Metabolic Disease
Clinical research activity includes atherosclerotic cardiovascular disease, myocardial infarction, heart failure, atrial fibrillation, cardiogenic shock, and transcatheter aortic valve implantation. The investigator is also involved in studies addressing lipoprotein(a), obesity, overweight, and renal impairment linked to cardiovascular risk.
- Acute coronary syndromes
- Heart failure with renal comorbidity
- Lipid-lowering and antithrombotic strategies
Additional interest extends to prevention of major cardiovascular events and management of overlapping cardiorenal disease.
Thoracic and Respiratory Disorders
The investigator is active in non-small cell lung cancer, small cell lung cancer, advanced NSCLC, COPD, severe asthma, pulmonary sarcoidosis, and respiratory tract infection. This includes work in both malignant and non-malignant airway disease.
- Lung cancer and thoracic oncology
- Chronic obstructive pulmonary disease
- Asthma with eosinophilic phenotype
Research also covers community-acquired pneumonia and infection-related cardiopulmonary complications.
Hematologic Malignancies
Research involvement spans acute myeloid leukemia, myelodysplastic syndrome, chronic lymphocytic leukemia, small lymphocytic lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, Hodgkin lymphoma, and multiple myeloma. The portfolio also includes myeloproliferative and related marrow disorders.
- Leukemia and marrow failure syndromes
- Lymphoma subtypes
- Plasma cell disorders
Therapeutic interests include antibody-based regimens, targeted agents, and treatment strategies for relapsed or refractory disease.
Breast, Gastrointestinal, and Genitourinary Cancers
The investigator participates in studies of breast cancer, including HER2-positive, HER2-low, triple-negative, and hormone receptor-positive disease, as well as gastric cancer, esophageal cancer, rectal cancer, colorectal cancer, pancreatic cancer, prostate cancer, urothelial cancer, and renal cell carcinoma.
- Breast cancer subtypes
- Colorectal and rectal cancer
- Prostate, urothelial, and kidney cancers
Key therapeutic themes include immunotherapy, antibody-drug conjugates, endocrine therapy, and organ-preserving approaches in gastrointestinal malignancies.
Autoimmune, Inflammatory, and Renal Conditions
Clinical interests also include rheumatoid arthritis, axial spondyloarthritis, Sjögren's disease, giant cell arteritis, gout, secondary hyperparathyroidism, chronic kidney disease, acute kidney injury, and urolithiasis.
- Autoimmune rheumatic disease
- Chronic kidney disease and acute renal injury
- Metabolic and inflammatory comorbidity
Research activity includes treatment evaluation in pulmonary sarcoidosis and renal-protective strategies in patients with complex multisystem disease.
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