Eva D. B.
- Country
- Belgium
- Department
- Hematology
Research Overview
- RADAR: A randomised phase III trial with a PET response adapted design comparing ABVD +/- ISRT with A2VD +/- ISRT in patients with previously untreated stage IA/IIA Hodgkin lymphoma
- Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial of Bleximenib, Venetoclax, and Azacitidine in Acute Myeloid Leukemia with KMT2A Rearrangements or NPM1 Mutations
- HOVON 181 AML: Bleximenib or Placebo in Combination with Standard Induction and Consolidation Therapy followed by Maintenance for the Treatment of Patients with Newly Diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia Eligible for Intensive Chemotherapy: a double-blind phase 3 study
Data & Insights
Has run more than one trial at 39 of 210 partner sites.
Specializations
Hematologic malignancies
Clinical research in hematology centers on aggressive and relapsed blood cancers, with involvement in lymphoma, multiple myeloma, and acute leukemia programs, including acute lymphoblastic leukemia and acute myeloid leukemia.
- Hodgkin lymphoma
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
- Multiple myeloma
Interest also extends to stem cell transplantation and advanced treatment strategies for refractory hematologic disease.
Breast and gynecologic oncology
Research activity includes a strong focus on breast cancer, especially hormone receptor-positive, HER2-negative, and metastatic breast cancer, alongside studies in ovarian cancer, endometrial cancer, and cervical cancer.
- Advanced breast cancer
- HER2-positive breast cancer
- Ovarian neoplasms
- Endometrial cancer
The therapeutic landscape also includes adjuvant and metastatic settings in solid tumor care.
Gastrointestinal and hepatobiliary disease
Clinical trials span colorectal cancer, gastric cancer, pancreatic cancer, biliary tract cancer, and liver-related disorders such as cirrhosis, hepatocellular carcinoma, primary biliary cholangitis, and non-alcoholic steatohepatitis.
- Inflammatory bowel disease
- Ulcerative colitis
- Crohn’s disease
- Portal hypertension
Research also covers hepatic encephalopathy, cholestatic pruritus, and other complications of chronic liver disease.
Thoracic and solid tumors
Another major area is thoracic oncology, with involvement in non-small cell lung cancer, small cell lung cancer, and head and neck squamous cell carcinoma, as well as broader solid tumor programs.
- Metastatic non-small cell lung cancer
- Esophageal cancer
- Neuroendocrine tumors
- Urothelial carcinoma
Work in this domain includes targeted therapy and immuno-oncology approaches across advanced malignancies.
Immune-mediated, neurologic, and cardiometabolic conditions
Research involvement also includes autoimmune disease and inflammatory disorders such as rheumatoid arthritis, multiple sclerosis, myasthenia gravis, and atopic dermatitis, together with selected neurologic and cardiometabolic conditions.
- Inflammatory bowel disease
- Epilepsy
- Atrial fibrillation
- Obesity
The portfolio further touches migraine, heart failure, and chronic obstructive pulmonary disease.
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