María Esther C. D.
- Country
- Spain
- Department
- 6302: Neurología
Research Overview
- Safety and Tolerability of RG6496 in Huntington’s Disease Gene Expansion Carriers with the Selected Genetic Variant (POINT‑HD)
- Randomized, Double‑Blind, Placebo‑Controlled Phase 3 Trial of Oral Votoplam in Adults with Huntington’s Disease Assessing cUHDRS Progression
- Evaluation of Long-Term Safety and Efficacy of PTC518 in Huntington's Disease: A Phase 2b Double-Blind, Randomized Extension Study
Data & Insights
Has run more than one trial at 74 of 200 partner sites.
Specializations
Movement disorders and neurodegenerative disease
Clinical research activity includes Parkinson’s disease, Huntington’s disease, multiple system atrophy, progressive supranuclear palsy, and Tourette syndrome, with attention to symptom control, disease progression, and functional outcomes.
- Parkinson’s disease
- Huntington’s disease
- Progressive supranuclear palsy
- Tourette syndrome
Areas of interest also include fatigue associated with Parkinson’s disease and genetic forms of movement disorders linked to GBA1 and huntingtin biology.
Multiple sclerosis and neuroimmunology
The investigator is involved in studies across relapsing multiple sclerosis, progressive forms of multiple sclerosis, secondary progressive multiple sclerosis, and pediatric multiple sclerosis, reflecting a strong therapeutic focus on inflammatory demyelinating disease.
- Relapsing multiple sclerosis
- Progressive forms of multiple sclerosis
- Secondary progressive multiple sclerosis
- Pediatric multiple sclerosis
Research interest extends to disease-modifying strategies aimed at reducing relapse activity and preserving neurological function.
Acute stroke and cerebrovascular disease
Clinical trial involvement includes acute ischemic stroke, high-risk transient ischemic attack, cerebral embolectomy, and prevention of recurrent ischemic events, with emphasis on vascular neurology and stroke recovery.
- Acute ischemic stroke
- High-risk transient ischemic attack
- Cerebral embolectomy
- Stroke prevention
Additional work addresses spontaneous intracerebral hemorrhage and spontaneous coronary artery dissection within the broader cerebrovascular field.
Neurodevelopmental and pediatric neurologic disorders
Research spans autism spectrum disorders, irritability associated with autistic disorder, pediatric multiple sclerosis, Tourette syndrome, and pediatric neuroinflammatory conditions, showing interest in neurologic disease across childhood and adolescence.
- Autism spectrum disorders
- Pediatric multiple sclerosis
- Tourette syndrome
- Neurodevelopmental disorders
Therapeutic involvement also includes conditions affecting behavior, cognition, and long-term neurological development.
Neurometabolic and rare neurologic diseases
The investigator’s portfolio includes late metachromatic leukodystrophy, Gaucher disease, ornithine transcarbamylase deficiency, methylmalonic acidemia, and propionic acidemia, indicating involvement in rare inherited disorders with neurological impact.
- Metachromatic leukodystrophy
- Gaucher disease
- Ornithine transcarbamylase deficiency
- Methylmalonic acidemia
Interest also extends to pharmacogenetics and other precision approaches relevant to neurologic and metabolic care.
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