Estela P. L.
- Country
- Spain
- Department
- Onología Médica
Research Overview
- ONC201 for the Treatment of Newly Diagnosed H3 K27M-mutant Diffuse Glioma Following Completion of Radiotherapy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study (The ACTION Study)
- Dose-Escalation Study of [177Lu]Lu-DOTA-TATE with Standard Care in Newly Diagnosed Glioblastoma and as Monotherapy in Recurrent Glioblastoma.
- Safety and Preliminary Efficacy of Azeliragon with Radiation and Temozolomide in Newly Diagnosed Glioblastoma Patients
Data & Insights
Has run more than one trial at 25 of 68 partner sites.
Specializations
Glioblastoma Treatment Innovation
This investigator specializes in developing novel therapeutic approaches for newly diagnosed glioblastoma, with particular focus on MGMT unmethylated cases. Their research explores alternative treatments to standard chemotherapy regimens.
- Combination therapy strategies
- MGMT methylation status assessment
- Post-surgical treatment optimization
The research encompasses evaluation of targeted therapies alongside conventional treatment methods.
Advanced Brain Cancer Research
The investigator conducts studies on diffuse glioma with specific genetic mutations, including H3 K27M-mutant variants. Their work includes investigation of targeted molecular therapies and radiotherapy combinations.
- Molecular targeted treatments
- Genetic mutation analysis
- Radio-therapeutic approaches
Research activities focus on personalized treatment strategies based on specific tumor characteristics.
Experimental Therapeutics
The investigator explores innovative therapeutic compounds for glioblastoma multiforme, including novel agents like radioligand therapies and experimental medications. Their research spans both newly diagnosed and recurrent cases.
- Novel drug development
- Treatment resistance mechanisms
- Therapeutic combination strategies
The work includes evaluation of survival outcomes and progression-free intervals in brain cancer patients.
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