Enrique G. D.
- Country
- Spain
- Department
- Oncology
Research Overview
- Evaluation of Safety, Pharmacokinetics, and Preliminary Efficacy of AMX-500 in Patients with Metastatic Castration-Resistant Prostate Cancer
- Phase I Study of XL092 Monotherapy and Combination Therapy in Advanced Solid Tumors: ccRCC, nccRCC, HR+ BC, mCRPC, and CRC
- A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)
Data & Insights
Has run more than one trial at 258 of 506 partner sites.
Specializations
Thoracic and Lung Cancer
Clinical activity is strongly centered on non-small cell lung cancer and small cell lung cancer, with additional interest in advanced solid tumors, EGFR-mutated disease, KRAS-mutant tumors, and RET or ROS1 rearranged malignancies.
- Advanced and metastatic lung cancer
- Resectable and unresectable thoracic malignancies
- Neuroendocrine lung tumors
- Biomarker-driven targeted oncology
The oncology portfolio also extends to mesothelioma, head and neck squamous cell carcinoma, and other advanced cancers requiring precision-based treatment strategies.
Breast and Gynecologic Oncology
Research involvement includes early breast cancer, metastatic breast cancer, triple-negative breast cancer, and HER2-positive or hormone receptor-positive disease, together with ovarian, endometrial, and cervical cancer.
- HER2-directed breast cancer
- Triple-negative and hormone receptor-positive breast cancer
- Advanced ovarian and endometrial cancer
- Locally advanced gynecologic malignancies
There is also participation in studies focused on adjuvant and neoadjuvant breast cancer management and treatment-resistant metastatic disease.
Genitourinary and Prostate Cancer
Another major focus is prostate cancer, including metastatic castration-resistant prostate cancer, metastatic castration-sensitive prostate cancer, and high-risk localized disease, alongside bladder cancer, urothelial carcinoma, and upper tract urothelial cancer.
- Advanced prostate cancer
- Muscle-invasive and non-muscle-invasive bladder cancer
- Metastatic urothelial carcinoma
- Renal cell carcinoma
Research also covers kidney transplantation-related complications and antibody-mediated rejection, broadening the therapeutic scope beyond oncology.
Autoimmune, Inflammatory, and Dermatologic Disease
Clinical work includes systemic lupus erythematosus, lupus nephritis, psoriatic arthritis, axial spondyloarthritis, ulcerative colitis, Crohn's disease, and Sjögren's syndrome.
- Autoimmune rheumatic disease
- Inflammatory bowel disease
- Chronic spontaneous urticaria
- Atopic dermatitis and hidradenitis suppurativa
Additional interest is seen in psoriasis, bullous pemphigoid, and other immune-mediated skin disorders with unmet therapeutic need.
Cardiometabolic, Renal, and Respiratory Medicine
The trial portfolio also includes atherosclerotic cardiovascular disease, atrial fibrillation, heart failure, myocardial infarction, chronic kidney disease, IgA nephropathy, and pulmonary hypertension.
- Cardiovascular risk reduction
- Chronic kidney disease and transplant medicine
- Asthma and severe respiratory disease
- Fibrotic liver disease and metabolic liver disorders
Respiratory and metabolic interests extend to asthma, idiopathic pulmonary fibrosis, NASH/MASH, and primary biliary cholangitis, reflecting a broad therapeutic reach across internal medicine.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.