Encarnação T.
- Country
- Portugal
- Department
- Serviço de Oncologia
Research Overview
- Dose-Escalation Study of Zongertinib in Patients with Advanced Non-Small Cell Lung Cancer and Solid Tumors with HER2 Aberrations
- Tarlatamab plus Durvalumab versus Durvalumab Alone in Patients with Extensive-Stage Small Cell Lung Cancer Following Platinum-Etoposide Therapy
- Phase II Evaluation of JDQ443 Monotherapy in KRAS G12C-Mutated NSCLC with Variable PD-L1 Expression and STK11 Co-Mutation
Data & Insights
Has run more than one trial at 24 of 140 partner sites.
Specializations
Dermatology and Inflammatory Skin Disease
Clinical research activity includes atopic dermatitis, hidradenitis suppurativa, psoriasis, prurigo nodularis, vitiligo, and atopic hand eczema, with a strong focus on immune-mediated skin disorders.
- Atopic dermatitis
- Hidradenitis suppurativa
- Psoriasis
- Vitiligo
- Prurigo nodularis
Research interests also extend to alopecia areata, female androgenetic alopecia, and chronic inflammatory skin conditions requiring targeted therapeutic options.
Cutaneous Autoimmunity and Systemic Lupus Erythematosus
The investigator is involved in studies of cutaneous lupus erythematosus, including subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus, as well as related autoimmune skin manifestations.
- Subacute cutaneous lupus erythematosus
- Chronic cutaneous lupus erythematosus
- Cutaneous lupus erythematosus
- Primary Sjögren’s disease
This area reflects an interest in therapies for refractory autoimmune dermatologic disease and associated systemic involvement.
Thoracic Oncology and Advanced Lung Cancer
Clinical trial involvement covers non-small cell lung cancer, metastatic NSCLC, KRAS G12C-mutated disease, EGFR-mutated lung cancer, and small cell lung cancer, with attention to advanced and treatment-resistant settings.
- Non-small cell lung cancer
- KRAS G12C-mutated NSCLC
- EGFR-mutated advanced NSCLC
- Extensive-stage small cell lung cancer
- Locally advanced unresectable NSCLC
Research interests include immunotherapy, targeted therapy, and combination approaches for advanced thoracic malignancies.
Breast Cancer and Hormone Receptor-Driven Malignancies
The investigator is active in studies of breast cancer, including early breast cancer, metastatic breast cancer, HER2-positive, HER2-low, and hormone receptor-positive disease.
- Early breast cancer
- HER2-positive breast cancer
- HER2-low breast cancer
- Hormone receptor-positive breast cancer
- Advanced breast cancer
Therapeutic interest also includes endocrine therapy combinations and treatment strategies for recurrent or metastatic disease.
Head and Neck Cancer, Cardiomyopathy, and Respiratory Disease
Additional research spans head and neck squamous cell carcinoma, hypertrophic cardiomyopathy, asthma, chronic obstructive pulmonary disease, and migraine, showing engagement across oncology and non-oncology therapeutic areas.
- Head and neck squamous cell carcinoma
- Hypertrophic cardiomyopathy
- Asthma
- Chronic obstructive pulmonary disease
- Migraine
There is also involvement in erosive esophagitis and thyroid eye disease, broadening the therapeutic scope beyond oncology and dermatology.
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