Emmanuelle B.
- Country
- France
- Department
- Oncologie médicale
Research Overview
- A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)
- Randomized Phase II/III Study of Cabozantinib Maintenance Versus Best Supportive Care in Osteosarcoma Patients After First‑Line Chemotherapy (FOSTER‑CabOS)
- (Peak) A Phase 3 Randomized, Open-label, Multicenter Clinical Study of CGT9486+Sunitinib vs Sunitinib in Subjects with Locally Advanced, Unresectable, or Metastatic Gastrointestinal Stromal Tumors
Data & Insights
Has run more than one trial at 226 of 462 partner sites.
Specializations
Thoracic oncology and lung cancer
Clinical research activity is strongly centered on non-small cell lung cancer, small cell lung cancer, and other advanced thoracic malignancies, with interest in both first-line and later-line treatment strategies, including immunotherapy, targeted approaches, and combined modality care.
- Non-small cell lung cancer
- Small cell lung cancer
- Pleural mesothelioma
- Unresectable stage III disease
Additional involvement includes EGFR exon 20 insertion disease, ROS1- and ALK-rearranged tumors, and treatment settings spanning locally advanced, metastatic, and recurrent disease.
Breast cancer and endocrine therapy
The investigator is active in hormone receptor-positive and HER2-negative breast cancer, with research spanning early, locally advanced, and metastatic settings, as well as treatment strategies aimed at relapse prevention and disease control.
- ER+/HER2- early breast cancer
- HER2-positive metastatic breast cancer
- HR+/HER2- advanced breast cancer
- Breast cancer recurrence prevention
Therapeutic interests also include endocrine-based treatment, PIK3CA-mutant disease, and strategies for patients with prior endocrine exposure or high risk of relapse.
Gynecologic oncology and urogenital cancers
Research involvement extends to endometrial cancer, ovarian cancer, cervical cancer, biliary tract cancer, and bladder cancer, reflecting a broad focus on advanced and recurrent gynecologic and genitourinary malignancies.
- Endometrial cancer
- Ovarian cancer
- Cervical cancer
- Urinary bladder neoplasms
Therapeutic interests include adjuvant and perioperative treatment, maintenance therapy, and approaches for recurrent or metastatic disease.
Neuro-oncology and central nervous system disorders
The investigator participates in studies involving glioblastoma, diffuse midline glioma, brainstem glioma, and neuroblastoma, alongside clinical work in broader neurology and neurodegenerative disease areas.
- Glioblastoma
- Diffuse midline glioma
- Diffuse intrinsic pontine glioma
- Parkinson’s disease
Additional interests include multiple sclerosis, Alzheimer’s disease, and mild cognitive impairment, indicating participation across both oncologic and neurologic therapeutic development.
Cardiometabolic, respiratory, and critical care medicine
Clinical research also covers cardiovascular disease, atrial fibrillation, stroke prevention, hypertrophic cardiomyopathy, and transthyretin-mediated amyloid cardiomyopathy, together with respiratory and intensive care conditions.
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
- Hospital-acquired pneumonia
- Atherosclerotic cardiovascular disease
Therapeutic interests include pulmonary hypertension, progressive pulmonary fibrosis, ventilator-associated pneumonia, and prevention of ischemic stroke and systemic embolism.
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