Elvire P. T.
- Country
- France
- Department
- Oncology medical
Research Overview
- A Randomized Phase 3 Study of Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab, with or without Platinum Chemotherapy, in Subjects with No Prior Therapy for Advanced or Metastatic PD-L1 TPS<50% Non-squamous Non-small Cell Lung Cancer without Actionable Genomic Alterations (TROPION-Lung07)
- Evaluation of Trastuzumab Deruxtecan with Immunotherapy and Chemotherapy in First-Line Treatment of HER2-Overexpressing Advanced Non-Small Cell Lung Cancer
- Evaluation of Repotrectinib and CYP450 Probe Cocktail in TKI-Pretreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Data & Insights
Has run more than one trial at 506 of 762 partner sites.
Specializations
Hematologic Malignancies
She directs trials targeting Acute Myeloid Leukemia across adult and pediatric cohorts. The program also addresses chronic lymphoid disorders such as chronic lymphocytic leukemia.
- Acute Myeloid Leukemia
- Chronic Lymphocytic Leukemia
- Multiple Myeloma
- Mantle Cell Lymphoma
- Myelodysplastic Syndromes
Recent initiatives explore combinatorial regimens for Multiple Myeloma relapse.
Solid Tumor Oncology
Her work includes investigations of Non‑Small Cell Lung Cancer with diverse genomic alterations. She also leads studies in breast and colorectal malignancies.
- Non‑Small Cell Lung Cancer
- Breast Cancer
- Colorectal Cancer
- Renal Cell Carcinoma
- Hepatocellular Carcinoma
Efforts extend to rare entities such as Merkel Cell Carcinoma.
Immunology and Autoimmune Disorders
The investigator examines therapeutic options for Systemic Lupus Erythematosus and related vasculitides. Research also covers immune‑mediated skin conditions.
- Systemic Lupus Erythematosus
- ANCA‑associated Vasculitis
- Atopic Dermatitis
- Psoriasis
- Hidradenitis Suppurativa
A focus on refractory disease includes Immune Thrombocytopenia.
Infectious Diseases and Mycobacterial Infections
She studies pulmonary infections caused by Mycobacterium avium complex in immunocompromised hosts. The portfolio also includes viral and fungal complications post‑transplant.
- Mycobacterium avium complex
- Cytomegalovirus infection
- Invasive Aspergillosis
- Clostridioides difficile infection
- HSV infections
Clinical protocols assess outcomes of nontuberculous mycobacterial lung disease treatment.
Stem Cell Transplantation and Cellular Therapy
Her clinical program integrates Allogeneic hematopoietic stem cell transplantation for high‑risk hematologic cancers. She also evaluates emerging CAR‑T cell approaches.
- Allogeneic HSCT
- CAR‑T cell therapy
- Haploidentical transplantation
- Reduced‑intensity conditioning
- Graft‑versus‑host disease prophylaxis
Long‑term follow‑up investigates immune reconstitution after stem cell transplant.
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