Elsmarieke V. D. G.
- Country
- The Netherlands
- Department
- Radiology and Nuclear Medicine
Research Overview
- Evaluation of Trontinemab Distribution, Binding, and Retention in the Brain of Healthy Subjects and Alzheimer’s Disease Patients
- Evaluation of Flortaucipir (18F) PET Imaging for Diagnostic Enhancement in Patients with Mild Cognitive Impairment and Dementia
- Phase 1 Evaluation of [18F]ACI-19626 as a PET Radioligand for Imaging TDP-43 Inclusions in Alzheimer's, ALS, FTD, and LATE Patients Compared to Healthy Controls
Data & Insights
Has run more than one trial at 1 of 6 partner sites.
Specializations
Molecular Imaging in Oncology
Advances in positron emission tomography and targeted radiotracers to improve detection and treatment monitoring of solid tumors.
- Neuroendocrine carcinoma imaging
- Non‑small cell lung cancer PET/CT assessment
- Breast cancer receptor‑specific tracers
- Pancreatic adenocarcinoma metabolic profiling
- Metastatic colorectal cancer whole‑body imaging
Research is conducted at Amsterdam UMC with a focus on integrating imaging biomarkers into therapeutic decision‑making.
Cardiovascular Nuclear Medicine
Application of radionuclide techniques to evaluate myocardial perfusion, viability, and vascular inflammation.
- Myocardial infarction scar quantification
- Atherosclerotic cardiovascular disease plaque activity
- Heart failure remodeling assessment
- Coronary artery disease ischemia detection
- Cardiac amyloidosis tracer uptake
The program leverages hybrid SPECT/CT platforms to guide personalized cardiovascular therapies.
Neuroimaging and Neurodegenerative Disorders
High‑resolution imaging strategies to characterize brain pathology in dementia and movement disorders.
- Alzheimer’s disease amyloid PET
- Parkinson’s disease dopaminergic imaging
- Multiple sclerosis lesion load evaluation
- Frontotemporal dementia metabolic mapping
- Neuroendocrine tumors central nervous system spread
Collaboration with neurology units enhances the translation of imaging findings into therapeutic pathways.
Pediatric Radiology and Metabolic Imaging
Specialized imaging protocols for congenital and metabolic diseases in children.
- Alpha‑1 antitrypsin deficiency liver assessment
- Congenital haemophilia A joint bleeding detection
- Phenylketonuria brain metabolism monitoring
- Premature infant apnea functional imaging
- Juvenile idiopathic arthritis synovial inflammation
Imaging protocols are optimized for low radiation dose while preserving diagnostic accuracy.
Interventional Radiology for Vascular and Oncology Applications
Image‑guided minimally invasive procedures to treat vascular lesions and deliver locoregional therapies.
- Transarterial chemo‑embolization for hepatocellular carcinoma
- Radiofrequency ablation of lung metastases
- Endovascular stenting in peripheral arterial disease
- Percutaneous biopsy of deep‑seated tumors
- Thermal ablation of renal cell carcinoma
Procedures are integrated with real‑time imaging to maximize therapeutic efficacy and safety.
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