Eleni T.
- Country
- Greece
- Department
- 2nd Pathology - Oncology Clinic
Research Overview
- Evaluation of Adagrasib Dosing Regimens in Previously Treated KRAS G12C-Mutant Non-Small Cell Lung Cancer Patients
- Phase 3 Randomized Study of Tucatinib, Trastuzumab, and mFOLFOX6 vs. mFOLFOX6 with Cetuximab or Bevacizumab in HER2+ Metastatic Colorectal Cancer
- Phase 3 Randomized Open-label Study of Imlunestrant, Abemaciclib, and Endocrine Therapy in ER+ HER2- Advanced Breast Cancer Post-Endocrine Treatment
Data & Insights
Has run more than one trial at 283 of 595 partner sites.
Specializations
Thoracic Oncology and Solid Tumors
Clinical research activity includes advanced and metastatic malignancies, with strong involvement in non-small cell lung cancer, melanoma, head and neck squamous cell carcinoma, urothelial carcinoma, breast cancer, and other solid tumors.
- Advanced/metastatic NSCLC
- Melanoma and advanced solid tumors
- Breast cancer and HER2-positive colorectal cancer
- Urothelial carcinoma and bladder cancer
- Head and neck cancer
Research interest also extends to biomarker-defined disease, including EGFR-mutant, KRAS G12C-mutant, and PD-L1-positive tumors, as well as MTAP-deleted thoracic and gastrointestinal cancers.
Dermatology and Immune-Mediated Skin Disease
The investigator is actively engaged in therapeutic studies for chronic inflammatory skin disorders, especially atopic dermatitis, hidradenitis suppurativa, plaque psoriasis, bullous pemphigoid, prurigo nodularis, and alopecia areata.
- Atopic dermatitis
- Hidradenitis suppurativa
- Plaque psoriasis
- Bullous pemphigoid
- Alopecia areata
Additional work covers vitiligo, cutaneous lupus erythematosus, primary discoid lupus erythematosus, vernal keratoconjunctivitis, and other pruritic and autoimmune dermatoses.
Cardiovascular, Thrombotic, and Metabolic Disease
Research involvement includes prevention and treatment strategies in atherosclerotic cardiovascular disease, acute coronary syndrome, myocardial infarction, atrial fibrillation, heart failure with reduced ejection fraction, and arterial hypertension.
- Atherosclerotic cardiovascular disease
- Acute ischemic stroke and transient ischemic attack
- Proximal deep vein thrombosis
- Type 2 diabetes and obesity
- Chronic kidney disease with cardiovascular risk
The therapeutic portfolio also includes lipid-lowering and antithrombotic approaches, along with studies in preeclampsia and stroke prevention.
Autoimmune, Inflammatory, and Neurologic Disorders
Clinical interests include systemic and organ-specific immune disease such as systemic lupus erythematosus, primary Sjögren’s disease, myositis, dermatomyositis, multiple sclerosis, and chronic inflammatory demyelinating polyneuropathy.
- Systemic lupus erythematosus and cutaneous lupus erythematosus
- Primary Sjögren’s disease
- Myositis and dermatomyositis
- Multiple sclerosis
- Chronic inflammatory demyelinating polyneuropathy
Additional therapeutic focus includes primary immunodeficiency diseases, major depressive disorder, and sepsis linked to immune dysregulation.
Gastrointestinal, Renal, and Infectious Disease
Research activity also spans ulcerative colitis, erosive esophagitis, gastroesophageal and pancreatic cancers, non-diabetic chronic kidney disease, end-stage kidney disease, and community-acquired pneumonia.
- Ulcerative colitis
- Chronic kidney disease and end-stage kidney disease
- Community-acquired pneumonia
- Sepsis
- Pancreatic and gastrointestinal cancers
Therapeutic interests include infection control, kidney protection, and management of metabolic complications in complex internal medicine settings.
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