Efstathios K.
- Country
- Greece
- Department
- Department of Clinical Therapeutics, Plasma Cell Dyscrasias Unit
Research Overview
- Evaluation of ABBV-383 for Safety and Efficacy in Patients with Light Chain Amyloidosis
- Phase 3 Study to Evaluate the Efficacy and Safety of Nucresiran in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy
- Phase III Randomized Open‑Label Study of Cevostamab Combination Therapy Versus Standard of Care in Relapsed/Refractory Multiple Myeloma After 1‑3 Prior Lines
Data & Insights
Has run more than one trial at 121 of 243 partner sites.
Specializations
Plasma Cell Disorders and Amyloidosis
Clinical research activity centers on multiple myeloma, smoldering myeloma, Waldenström macroglobulinemia, and AL amyloidosis, including transthyretin amyloidosis with cardiac involvement and polyneuropathy.
- Relapsed and refractory multiple myeloma
- Newly diagnosed multiple myeloma
- AL amyloidosis
- Waldenström macroglobulinemia
- Transthyretin amyloid cardiomyopathy
Research interest extends to disease control, residual disease assessment, and organ-specific complications in advanced hematologic malignancies.
Thoracic and Solid Tumor Oncology
The investigator is involved in trials across non-small cell lung cancer, small cell lung cancer, breast cancer, ovarian cancer, endometrial cancer, and urothelial carcinoma.
- Non-small cell lung cancer
- Small cell lung cancer
- Breast cancer
- Endometrial cancer
- Urothelial cancer
Work also includes KRAS G12C-mutant disease, HER2-directed strategies, and advanced metastatic solid tumors.
Cardiovascular and Thromboinflammatory Disease
Research spans heart failure, myocardial infarction, atherosclerotic cardiovascular disease, and stroke prevention, with attention to inflammatory pathways and cardiometabolic risk.
- Heart failure with preserved or reduced ejection fraction
- Acute myocardial infarction
- Atherosclerotic cardiovascular disease
- Acute ischemic stroke
- Obesity-related cardiovascular risk
Additional interest includes cardiac amyloidosis and prevention of recurrent major adverse cardiovascular events.
Immune-Mediated and Inflammatory Disorders
Clinical involvement includes Crohn’s disease, ulcerative colitis, sepsis, primary immune thrombocytopenia, and hematopoietic stem cell transplant-associated thrombotic microangiopathy.
- Crohn’s disease
- Ulcerative colitis
- Sepsis
- Primary immune thrombocytopenia
- Thrombotic microangiopathy
The therapeutic scope also covers immune dysregulation in infection-related and transplant-related complications.
Genitourinary and Gynecologic Malignancies
Research activity includes prostate cancer, renal cell carcinoma, bladder cancer, cervical cancer, and ovarian and fallopian tube cancers.
- Metastatic prostate cancer
- Renal cell carcinoma
- Muscle-invasive bladder cancer
- Cervical cancer
- Ovarian and fallopian tube cancer
Interest also includes endometrial carcinoma, urothelial carcinoma, and maintenance strategies in recurrent gynecologic disease.
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