Edward M.
- Country
- Ireland
- Department
- Department of Respiratory Medicine
Research Overview
- Phase 2 Randomized Double‑Blind Study of VX-828/Deutivacaftor With and Without Tezacaftor in Adults with Cystic Fibrosis
- Evaluation of Long-term Safety and Efficacy of Tezacaftor, Deutivacaftor, and Vanzacaftor Combination Therapy in Patients with Cystic Fibrosis
- Evaluation of Nebulized BX004 in Adult Cystic Fibrosis Patients with Chronic Pseudomonas aeruginosa Pulmonary Infection: A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 35 of 85 partner sites.
Specializations
Respiratory medicine and airway disease
Clinical research activity includes asthma, severe asthma with an eosinophilic phenotype, chronic obstructive pulmonary disease, bronchiectasis, and cystic fibrosis, with additional interest in idiopathic pulmonary fibrosis and progressive pulmonary fibrosis.
- Asthma
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
The therapeutic focus also extends to severe community-acquired pneumonia, critical respiratory illness, and hospital-based management of acute respiratory infections.
Thoracic oncology and solid tumours
Research involvement spans non-small cell lung cancer, lung cancer, advanced non-small cell lung cancer, and resected stage II-IIIA non-small cell lung cancer, alongside broader work in melanoma, renal cell carcinoma, and urothelial cancer.
- Non-small cell lung cancer
- Melanoma
- Renal cell carcinoma
Additional disease areas include hepatocellular carcinoma, gastric cancer, pancreatic cancer, and colorectal cancer, reflecting a strong interest in advanced malignancies.
Breast cancer and endocrine-driven malignancy
Clinical trial activity includes early breast cancer, HER2-positive breast cancer, HER2-negative breast cancer, triple negative breast cancer, and hormone receptor-positive breast cancer, with attention to both early-stage and metastatic disease.
- HER2-positive breast cancer
- Triple negative breast cancer
- Hormone receptor-positive breast cancer
Related activity also includes ovarian cancer, endometrial carcinoma, prostate cancer, and HER2-altered solid tumours.
Autoimmune, inflammatory, and renal disease
Investigator involvement covers idiopathic inflammatory myopathy, systemic sclerosis, Sjögren’s disease, IgA nephropathy, primary membranous nephropathy, and autoimmune pulmonary alveolar proteinosis.
- Idiopathic inflammatory myopathy
- Systemic sclerosis
- IgA nephropathy
Therapeutic interests also include Crohn’s disease, ulcerative colitis, and hidradenitis suppurativa, indicating a broad focus on immune-mediated disorders.
Infectious disease, critical care, and hematologic conditions
Research activity includes COVID-19, mpox virus disease, HIV infection, and severe pneumonia, together with studies in critically ill patients requiring advanced hospital care.
- COVID-19
- HIV infection
- Mpox virus disease
Additional interest extends to acute myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, and Hodgkin lymphoma, alongside work in stroke and anticoagulation reversal.
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