E. K.
- Country
- Austria
- Department
- Hematology
Research Overview
Data & Insights
Has run more than one trial at 0 of 138 partner sites.
Specializations
Acute Myeloid Leukemia
Research concentrates on innovative targeted therapies and cellular immunotherapy for Acute Myeloid Leukemia.
- Targeted FLT3 inhibition
- IDH1/2 mutation‑directed therapy
- Cellular CAR‑T approaches
- MRD‑guided treatment strategies
Clinical activity is evaluated in both newly diagnosed and relapsed settings.
Chronic Lymphocytic Leukemia
The investigator focuses on BTK inhibition, venetoclax combinations, and therapy for frail elderly patients with Chronic Lymphocytic Leukemia.
- BTK inhibitor ibrutinib and next‑generation agents
- Venetoclax‑based fixed‑duration regimens
- Treatment of high‑risk cytogenetics (del(17p), TP53)
- Therapy in patients ≥80 years or frail
Outcomes measured include progression‑free survival and overall survival.
Multiple Myeloma
Investigation centers on antibody‑drug conjugates, immunomodulatory agents, and maintenance strategies for Multiple Myeloma.
- Isatuximab in combination therapies
- Lenalidomide‑based maintenance
- CAR‑T cell therapy for relapsed/refractory disease
- Oral azacitidine post‑autologous transplant
Focus is on achieving MRD negativity.
Myelodysplastic Syndromes
Evaluation of hypomethylating agents and venetoclax combinations in higher‑risk Myelodysplastic Syndromes.
- Azacitidine plus venetoclax
- Oral azacitidine versus placebo
- Risk stratification using IPSS‑R
- Stem cell transplant eligibility
Aim is to improve event‑free survival.
Lymphoma
Trials explore BTK inhibitors, bispecific antibodies, and chemo‑immunotherapy optimization for various lymphoma subtypes.
- Zanubrutinib with anti‑CD20 antibodies
- Bispecific antibody glofitamab
- Polatuzumab‑based salvage regimens
- De‑escalated MATRix protocols
Targeting both indolent and aggressive disease forms.
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