Domenico R.
- Country
- Italy
- Department
- Centro Trapianto Midollo Osseo Adulti
Research Overview
- Efficacy of MC0518 Allogeneic Mesenchymal Stromal Cells in Adult Patients with Grade II–IV Acute Graft-Versus-Host Disease Refractory to Corticosteroids and Ruxolitinib
- Phase 3 Evaluation of Venetoclax and Azacitidine Post-Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Patients
- Phase 3 Randomized Controlled Trial of Pacritinib Versus Physician's Choice in Myelofibrosis Patients with Severe Thrombocytopenia
Data & Insights
Has run more than one trial at 71 of 186 partner sites.
Specializations
Hematologic Malignancies
Clinical activity includes a broad range of lymphoid and myeloid cancers, with interest in acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, and multiple myeloma.
- Non-Hodgkin lymphoma
- Hodgkin lymphoma
- Myelodysplastic syndromes
- Myelofibrosis
Research also extends to relapsed and refractory disease, cellular therapies, and transplant-related oncology.
Solid Tumors
The investigator is involved in treatment development for breast cancer, ovarian cancer, non-small cell lung cancer, head and neck squamous cell carcinoma, and endometrial cancer.
- Prostate cancer
- Renal cell carcinoma
- Urothelial carcinoma
- Melanoma
Therapeutic interest includes targeted oncology, immunotherapy, and maintenance strategies across advanced and recurrent solid tumors.
Autoimmune and Inflammatory Disorders
Research covers systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, psoriatic arthritis, and systemic sclerosis, reflecting strong involvement in immune-mediated disease.
- Atopic dermatitis
- Hidradenitis suppurativa
- Ulcerative colitis
- Crohn’s disease
Additional interest includes vasculitis, myositis, and IgG4-related disease.
Neurology and Neurodegenerative Disease
Clinical trials include Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease, multiple sclerosis, and schizophrenia, showing a wide therapeutic reach in central nervous system disorders.
- Lewy body dementia
- mild cognitive impairment
- psychosis
- treatment-resistant schizophrenia
Work also spans neuroinflammatory and neurodegenerative conditions with unmet therapeutic need.
Cardiometabolic, Renal, and Respiratory Disease
The investigator is active in heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, chronic kidney disease, and end-stage kidney disease, alongside stroke prevention and cardiorenal risk reduction.
- IgA nephropathy
- hypertension
- chronic obstructive pulmonary disease
- asthma
Interest also includes interstitial lung disease, pulmonary hypertension, and inflammatory cardiovascular conditions.
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