Domenica Immacolata B.
- Country
- Italy
- Department
- U.O.C. Pediatric Neuropsychiatry
Research Overview
- A Randomized Phase 2 Study of Adjunctive EQU-001 for Uncontrolled Focal Onset Seizures
- Phase 3 Randomized, Double‑Blind, Placebo‑Controlled Study of Oral Fenfluramine Hydrochloride in Participants with Rett Syndrome
- Evaluation of Radiprodil's Safety, Tolerability, and Pharmacokinetics in Tuberous Sclerosis Complex and Focal Cortical Dysplasia Type II Patients
Data & Insights
Has run more than one trial at 140 of 235 partner sites.
Specializations
Pediatric Neuropsychiatry and neurodevelopmental disorders
Clinical research activity includes conditions managed within pediatric neuropsychiatry, with attention to epilepsy, developmental and epileptic encephalopathies, autism-related neurobehavioral syndromes, and other disorders affecting cognition, behavior, and neurological development.
- Childhood absence epilepsy
- Dravet syndrome
- Refractory focal onset epilepsy
- Developmental and epileptic encephalopathies
- Neurocognitive disorders
Interest extends to therapeutic strategies for seizure control, long-term neurological follow-up, and interventions aimed at improving neurobehavioral outcomes in children and adolescents.
Autoimmune and inflammatory disease
The investigator is involved in trials across autoimmune diseases and chronic inflammatory conditions, including lupus, myasthenia gravis, rheumatoid arthritis, systemic sclerosis, and idiopathic inflammatory myopathies.
- Systemic lupus erythematosus
- Lupus nephritis
- Generalized myasthenia gravis
- Systemic sclerosis
- Idiopathic inflammatory myopathy
Therapeutic interest includes immune modulation for organ-specific and systemic disease manifestations, with emphasis on controlling inflammation and preserving function.
Oncology and hematologic malignancies
Research involvement spans a broad oncologic portfolio, with particular activity in breast cancer, ovarian cancer, lung cancer, lymphoma, and other solid tumors and blood cancers.
- Breast cancer
- Ovarian cancer
- Non-small cell lung cancer
- Chronic lymphocytic leukemia
- Diffuse large B-cell lymphoma
Therapeutic focus includes targeted treatment approaches, immune-based oncology, and precision strategies for advanced, recurrent, and treatment-resistant malignancies.
Respiratory, gastrointestinal, and hepatic disorders
Clinical trial activity also covers chronic diseases of the airways, digestive system, and liver, including asthma, chronic obstructive pulmonary disease, Crohn’s disease, ulcerative colitis, and non-alcoholic steatohepatitis.
- Severe asthma
- Chronic obstructive pulmonary disease
- Crohn’s disease
- Ulcerative colitis
- Non-alcoholic steatohepatitis
Interest is directed toward therapies for inflammatory control, symptom reduction, and prevention of progressive tissue damage in chronic organ disease.
Neuromuscular and rare genetic diseases
The investigator is also active in studies of rare neurological and genetic conditions, including spinal muscular atrophy, Duchenne muscular dystrophy, myotonic dystrophy, Rett syndrome, and Angelman syndrome.
- Spinal muscular atrophy
- Duchenne muscular dystrophy
- Myotonic dystrophy
- Rett syndrome
- Angelman syndrome
Therapeutic interest includes disease-modifying approaches for inherited neuromuscular impairment and long-term management of rare pediatric-onset disorders.
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