Dobrin S.
- Country
- Bulgaria
- Department
- Clinical Research unit
Research Overview
- Phase I Study on the Impact of Erythromycin-Mediated CYP3A4/5 Inhibition on CHF6001 Pharmacokinetics in Healthy Volunteers
- Effect of Enzalutamide, Apalutamide, and Bicalutamide on the Pharmacokinetics of Fezolinetant in Men with Prostate Cancer and Associated Hot Flashes
- Evaluation of Nicotine Resinate 1.5mg Lozenge on Craving Reduction in Moderate Smokers: A Randomized, Double-Blind, Placebo-Controlled Trial
Data & Insights
Has run more than one trial at 1 of 7 partner sites.
Specializations
Pharmacokinetic Studies
Investigates the interaction between CYP3A4/5 enzymes and drug metabolism, specifically examining the effects of erythromycin on drug absorption and elimination patterns.
- Drug-Drug Interactions
- Metabolic Pathways
- Absorption Kinetics
Focuses on understanding complex pharmaceutical interactions in healthy subjects.
Bioavailability Research
Conducts comparative studies on dofetilide administration routes, analyzing the pharmacokinetic profiles of intravenous versus oral formulations.
- Drug Delivery Systems
- Comparative Bioavailability
- Safety Assessment
Examines therapeutic equivalence across different drug delivery methods.
Smoking Cessation Therapeutics
Evaluates the efficacy of nicotine replacement therapy through lozenge formulation, focusing on craving reduction in moderate smokers.
- Craving Management
- Addiction Treatment
- Behavioral Response
Specializes in acute interventions for smoking cessation support.
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