Desamparados R. P.
- Country
- Spain
- Department
- Oncología Medica
Research Overview
Data & Insights
Has run more than one trial at 89 of 172 partner sites.
Specializations
Advanced Breast Oncology
Focuses on Estrogen Receptor Positive HER2 Negative Advanced Breast Cancer across metastatic and early disease settings.
- ER+/HER2- metastatic disease
- Neoadjuvant endocrine strategies
- CDK4/6 inhibitor resistance
- PIK3CA‑mutated breast tumors
- Biomarker‑driven patient selection
Research integrates targeted agents with endocrine regimens to improve survival outcomes.
Hematologic Malignancies
Investigates Acute Myeloid Leukemia, myelodysplastic syndromes and a spectrum of lymphoid cancers.
- AML with measurable residual disease
- MDS risk stratification
- IDH‑mutated myeloid disease
- Mantle cell lymphoma therapies
- T‑cell lymphoma immunomodulation
Efforts aim to translate molecular profiling into precision treatment pathways.
Solid Tumor Genomics
Targets cancers driven by specific oncogenic alterations such as the KRAS G12C mutation in colorectal and lung malignancies.
- KRAS‑driven colorectal cancer
- KRAS G12C NSCLC
- BRAF V600E colorectal disease
- MET‑amplified tumors
- FGFR2b‑positive gastric cancers
Genomic selection guides enrollment in targeted‑agent studies.
Cardiovascular and Hepatic Critical Care
Addresses acute coronary events, heart failure phenotypes and acute‑on‑chronic liver failure, including Acute Coronary Syndrome.
- Post‑MI left ventricular dysfunction
- Heart failure with preserved ejection fraction
- Atherosclerotic cardiovascular disease
- ACLF with multi‑organ failure
- Thromboembolic risk in atrial fibrillation
Clinical work seeks novel anti‑inflammatory and metabolic interventions.
Immune‑Mediated and Autoimmune Disorders
Explores systemic autoimmune conditions such as Systemic Lupus Erythematosus, inflammatory bowel disease and severe asthma.
- SLE renal involvement
- Crohn’s disease activity
- Severe eosinophilic asthma
- Psoriatic arthritis
- Pulmonary hypertension with heart failure
Studies evaluate cytokine blockade and pathway‑specific agents.
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