François D.
- Country
- France
- Department
- Anesthésie-Réanimation
Research Overview
- Evaluation of Ionized Calcium Target Adjustment on Regional Citrate Anticoagulation Efficacy in Continuous Renal Replacement Therapy Using Sodium Chloride and Sodium Citrate
- Effect of Adjuvant Ketamine on Recovery from Critical Illness in Adult Patients Requiring Unplanned Invasive Mechanical Ventilation: A Multicenter Randomized Controlled Trial
- Evaluation of Recombinant Human Interferon Gamma 1b in Post-Aggressive Immunosuppression in ICU Patients: A Randomized Double-Blind Controlled Trial
Data & Insights
Has run more than one trial at 16 of 51 partner sites.
Specializations
Anesthesiology and Intensive Care Medicine
Clinical research activity is centered in Anesthesie Reanimation, with involvement in perioperative care, critical care, and management of unstable adult patients in the intensive care unit.
- Sepsis and septic shock
- Acute respiratory failure and mechanical ventilation
- Cardiogenic shock and cardiac arrest
- Acute kidney injury in critical illness
The portfolio also includes care pathways for post-resuscitation syndromes, organ dysfunction in the ICU, and support strategies for patients requiring advanced hemodynamic or respiratory assistance.
Hematology and Hematologic Malignancies
The investigator is active in studies of blood cancers and marrow disorders, with a strong focus on therapeutic innovation in acute leukemias, lymphomas, and myelodysplastic syndromes.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma and other B-cell lymphomas
- Multiple myeloma and myelofibrosis
Research interests extend to relapsed or refractory disease, transplant-related complications, and novel immune-based and targeted approaches in hematologic oncology.
Oncology and Solid Tumors
Work in oncology spans a broad range of advanced and metastatic malignancies, with particular attention to tumor types where systemic therapy and immunotherapy continue to reshape clinical practice.
- Non-small cell lung cancer
- Breast cancer
- Gastrointestinal cancers including colorectal cancer and gastric cancer
- Hepatocellular carcinoma and urothelial carcinoma
Additional interest is seen in melanoma, sarcoma, head and neck cancers, ovarian cancer, pancreatic cancer, and biomarker-defined solid tumors.
Autoimmune and Inflammatory Diseases
The investigator contributes to clinical research in immune-mediated disorders affecting multiple organs, including systemic, renal, pulmonary, and dermatologic disease.
- Systemic lupus erythematosus and lupus nephritis
- Rheumatoid arthritis and psoriatic arthritis
- Sjögren’s disease and systemic sclerosis
- Vasculitis, inflammatory myopathies, and inflammatory bowel disease
This area also includes atopic dermatitis, hidradenitis suppurativa, and other chronic inflammatory conditions requiring targeted immunomodulation.
Respiratory, Cardiovascular, and Transplant-Related Disorders
Research interests also cover complex medical disorders seen in acute and chronic hospital care, including pulmonary vascular disease, heart disease, and complications after transplantation.
- Pulmonary arterial hypertension and interstitial lung disease
- Heart failure, myocardial infarction, and atrial fibrillation
- Kidney transplant rejection and transplant-associated thrombotic microangiopathy
- Thromboembolic disease and stroke
These studies align with therapeutic areas involving organ support, post-transplant management, and prevention of major cardiovascular and thrombotic complications.
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