Dennis W.
- Country
- Germany
- Department
- N/A
Research Overview
- A Randomized, Placebo‑Controlled Trial of Zenagamtide (NNC0487‑0111) in Obese Patients with HFpEF or HFmrEF to Reduce CV Death and HF Hospitalization
- Phase III Randomized Double‑Blind Trial of Elecoglipron (AZD5004) on Cardiovascular Mortality and Hospitalization in Adults with HFpEF or HFmrEF on Background Dapagliflozin
- Phase 2b Randomized Double‑Blind Dose‑Finding Study of YMI024 on Inflammatory Markers in Adults with Stable Coronary Artery Disease and Elevated hsCRP
Data & Insights
Has run more than one trial at 282 of 893 partner sites.
Specializations
Hematologic Malignancies and Transplantation
Clinical research activity includes acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, myelodysplastic syndromes, lymphoma, and myelofibrosis, with additional interest in hematopoietic stem cell transplantation and graft-versus-host disease.
- Acute myeloid leukemia
- Acute lymphoblastic leukemia
- Multiple myeloma
- Myelodysplastic syndromes
- Graft-versus-host disease
His work also extends to high-risk blood cancers requiring transplant-based or targeted treatment strategies, including chronic myeloid leukemia, chronic lymphocytic leukemia, and diffuse large B-cell lymphoma.
Autoimmune, Inflammatory, and Rheumatologic Disorders
He is involved in studies of rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, Sjögren’s disease, systemic sclerosis, polymyalgia rheumatica, and vasculitis.
- Rheumatoid arthritis
- Psoriatic arthritis
- Systemic lupus erythematosus
- Sjögren’s disease
- Systemic sclerosis
Additional therapeutic focus includes autoinflammatory disease, juvenile idiopathic arthritis, dermatomyositis, and eosinophilic granulomatosis with polyangiitis.
Solid Tumors and Precision Oncology
His trial portfolio covers breast cancer, non-small cell lung cancer, melanoma, ovarian cancer, gastroesophageal junction cancer, colorectal cancer, and pancreatic cancer.
- Breast cancer
- Non-small cell lung cancer
- Melanoma
- Ovarian cancer
- Pancreatic cancer
Research interest also includes urothelial cancer, renal cell carcinoma, cholangiocarcinoma, head and neck squamous cell carcinoma, and other advanced solid tumors with molecularly defined targets.
Neurology, Epilepsy, and Neurodegenerative Disease
He is active in clinical studies of epilepsy, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, dementia, and myasthenia gravis.
- Epilepsy
- Multiple sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Myasthenia gravis
His neurological research also includes tuberous sclerosis complex, spinal muscular atrophy, Duchenne muscular dystrophy, and rare seizure disorders.
Cardiometabolic, Pulmonary, and Gastrointestinal Disease
His clinical interests include heart failure, atrial fibrillation, coronary artery disease, atherosclerotic cardiovascular disease, and acute coronary syndrome, alongside pulmonary arterial hypertension and thromboembolic disease.
- Heart failure
- Atrial fibrillation
- Coronary artery disease
- Pulmonary arterial hypertension
- Thromboembolic disease
He also participates in studies of Crohn’s disease, ulcerative colitis, primary sclerosing cholangitis, idiopathic pulmonary fibrosis, sarcoidosis, and metabolic dysfunction-associated steatotic liver disease.
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