Declan O.
- Country
- Ireland
- Department
- Neurology
Research Overview
- Evaluation of Safety, Tolerability, and Efficacy of DYNE-251 in Duchenne Muscular Dystrophy Patients Amenable to Exon 51 Skipping
- Efficacy and Safety Evaluation of Casimersen and Golodirsen in Duchenne Muscular Dystrophy Patients Amenable to Exon 45 or 53 Skipping: A Double-Blind, Placebo-Controlled Study
- Phase 3 Randomized, Double-Blind, Placebo-Controlled Study of Omaveloxolone in Pediatric Friedreich’s Ataxia Patients Aged 2 to <16 Years
Data & Insights
Has run more than one trial at 7 of 28 partner sites.
Specializations
Neuromuscular Disorders
This investigator specializes in treating Duchenne Muscular Dystrophy (DMD), with particular expertise in genetic-based therapeutic approaches. Their clinical research focuses on innovative treatments for patients with specific genetic variations amenable to exon skipping therapy.
- Exon 45 skipping treatments
- Exon 51 skipping therapeutics
- Exon 53 skipping approaches
The investigator evaluates novel therapeutic compounds targeting muscle function and ambulation improvement in DMD patients.
Muscle Function Assessment
Their expertise extends to evaluating muscle function and mobility in neuromuscular disease patients, with specific focus on quantitative assessment methods.
- Ambulation velocity measurement
- Muscle strength evaluation
- Functional mobility assessment
The investigator employs specialized protocols to measure therapeutic effects on physical capabilities in DMD patients.
Protein Expression Studies
The investigator conducts research examining dystrophin protein expression in muscle tissue, focusing on therapeutic interventions that may enhance protein production in DMD patients.
- Muscle tissue analysis
- Protein level assessment
- Therapeutic response monitoring
Their work includes evaluation of protein expression changes following administration of investigational treatments.
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