David V.
- Country
- Czechia
- Department
- Oddeleni radioterapie a onkologie
Research Overview
- Comparative Study of JPB898 and Nivolumab in Combination with Ipilimumab for Advanced Unresectable/Metastatic Melanoma
- Efficacy and Safety of PF-08634404 Plus Combination Therapy Versus Pembrolizumab Plus Combination Therapy in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-641)
Data & Insights
Has run more than one trial at 55 of 275 partner sites.
Specializations
Thoracic Oncology
Non-small cell lung cancer is a major area of clinical interest, including advanced disease, ALK-positive tumors, HER2-mutated disease, and c-Met overexpressing subtypes.
- Advanced and metastatic NSCLC
- ALK-positive lung cancer
- HER2-driven lung cancer
- c-Met targeted therapy in lung cancer
The oncology portfolio also includes treatment-resistant and previously treated lung cancer settings, with attention to targeted and immune-based approaches.
Breast and Gynecologic Malignancies
Clinical activity includes breast cancer, ovarian cancer, endometrial cancer, cervical cancer, and related peritoneal and fallopian tube neoplasms.
- HR-positive and HER2-negative breast cancer
- HER2-positive and triple-negative breast cancer
- Platinum-resistant ovarian cancer
- Advanced endometrial and cervical cancer
Research involvement spans recurrent, metastatic, and treatment-refractory gynecologic and breast cancer populations, with emphasis on precision oncology and maintenance strategies.
Prostate and Colorectal Cancer
The investigator is involved in studies of prostate cancer across localized, hormone-sensitive, and castration-resistant settings, as well as colorectal cancer with molecularly defined disease.
- Metastatic castration-resistant prostate cancer
- Metastatic hormone-sensitive prostate cancer
- High-risk localized prostate cancer
- dMMR/MSI-H resectable colon cancer
These areas reflect a focus on advanced genitourinary oncology and biomarker-selected gastrointestinal malignancy.
Dermatology and Immune-Mediated Disease
Another active domain is atopic dermatitis, plaque psoriasis, and atopic hand eczema, alongside broader immune-mediated skin disease.
- Moderate-to-severe atopic dermatitis
- Moderate-to-severe plaque psoriasis
- Atopic hand eczema
- Pediatric and adolescent dermatologic disease
Trial involvement also extends to chronic inflammatory skin conditions requiring long-term symptom control and disease modification.
Renal, Cardiometabolic, and Supportive Care
Additional clinical interests include immunoglobulin A nephropathy, chronic kidney disease, dialysis-related anemia, atherosclerotic cardiovascular disease, and knee osteoarthritis.
- IgA nephropathy and proteinuria
- Anemia in chronic kidney disease
- Cardiovascular risk reduction
- Osteoarthritis pain management
These studies broaden the therapeutic scope beyond oncology into renal, cardiovascular, and symptom-focused care.
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