David R.
- Country
- Italy
- Department
- Dipartimento Cardiovascolarex
Research Overview
Data & Insights
Has run more than one trial at 0 of 55 partner sites.
Specializations
Cardiovascular Disease
The investigator concentrates on atherosclerotic cardiovascular disease and its acute manifestations, including myocardial infarction and major adverse cardiac events.
- Anti‑inflammatory therapy in post‑myocardial infarction patients
- Composite cardiovascular outcomes in heart failure cohorts
- Targeted vascular event reduction strategies
Research activities are conducted through the Azienda Sanitaria Locale Bari.
Migraine Therapeutics
Focus is placed on both acute and preventive approaches for migraine, spanning pediatric to adolescent populations.
- Preventive migraine treatment trials in adolescents
- Safety evaluation of acute migraine agents in children
- Long‑term intermittent migraine therapy assessment
Studies address chronic and episodic migraine subtypes.
Metastatic Colorectal Cancer
Research targets unresectable left‑sided RAS/B‑RAF wild‑type metastatic colorectal cancer with novel treatment scheduling.
- Intermittent versus continuous chemotherapy regimens
- Exploration of biomarkers for primary and secondary resistance
- Monitoring of treatment efficacy and toxicity in tissue and blood samples
Clinical investigations aim to improve quality of life and tolerability.
Meningioma Management
Efforts are directed toward grade 2 and 3 meningioma after surgery and radiotherapy.
- Evaluation of Regorafenib in recurrent meningioma
- Progression‑free survival as a primary endpoint
- Assessment of treatment impact on tumor biology
Multicenter randomized designs support the therapeutic assessment.
Sex‑Specific Heart Failure Optimization
Investigations address gaps in guideline‑directed medical therapy for women with heart failure.
- Up‑titration strategies versus usual care in female patients
- Impact on morbidity, mortality, and quality of life
- Adherence, dose reduction, and side‑effect monitoring
Prospective pragmatic trials evaluate real‑world implementation.
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