David O. H.
- Country
- Spain
- Department
- Oncología
Research Overview
- Evaluation of the Biological Effects of Saruparib (AZD5305) and Darolutamide, Alone and in Combination, in Patients with Newly Diagnosed Prostate Cancer Undergoing Radical Prostatectomy
- Evaluation of M9466 Monotherapy and Combination Therapy in Patients with Advanced Solid Tumors
- A Phase 2, Randomized, Open-Label Study of Two Dose Levels of Vobramitamab Duocarmazine in Participants with Metastatic Castration-Resistant Prostate Cancer (TAMARACK)
Data & Insights
Has run more than one trial at 41 of 179 partner sites.
Specializations
Thoracic and Upper Aerodigestive Tract Oncology
Clinical research activity includes a strong focus on non-small cell lung cancer, small cell lung cancer, and other thoracic malignancies, together with trials in head and neck squamous cell carcinoma and related advanced solid tumors.
- Non-small cell lung cancer
- Small cell lung cancer
- Head and neck squamous cell carcinoma
- Thoracic malignancies
The portfolio also extends to biomarker-defined disease subsets, including EGFR-mutated, ALK-rearranged, ROS1-positive, and RET-altered cancers.
Breast and Gynecologic Cancer
Research interests cover breast cancer across hormone receptor-positive, HER2-negative, HER2-positive, triple-negative, and metastatic settings, as well as ovarian cancer, endometrial cancer, cervical cancer, and other gynecologic malignancies.
- Breast cancer
- Ovarian cancer
- Endometrial cancer
- Cervical cancer
Work in this area includes interest in HER2-directed approaches, PIK3CA-mutated disease, and advanced or recurrent tumors with limited treatment options.
Genitourinary and Renal Malignancies
The investigator is involved in studies of urothelial carcinoma, bladder cancer, renal cell carcinoma, and prostate cancer, including metastatic, locally advanced, and treatment-resistant disease.
- Urothelial carcinoma
- Renal cell carcinoma
- Prostate cancer
- Bladder cancer
Therapeutic interest also includes molecularly selected subsets such as mCRPC, mCSPC, and FGFR-altered urothelial disease.
Hematologic Malignancies
Clinical trial involvement spans lymphoma, multiple myeloma, acute myeloid leukemia, myelodysplastic syndromes, and other myeloid neoplasms.
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Acute myeloid leukemia
- Myelodysplastic syndromes
Research activity also includes mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia, with emphasis on relapsed or refractory hematologic disease.
Precision Oncology and Advanced Solid Tumors
The investigator’s broader oncology program includes advanced solid tumors with actionable alterations such as KRAS, IDH, HER2, MET, and BRAF, alongside disease-agnostic studies in biomarker-selected populations.
- Advanced solid tumors
- Biomarker-selected cancers
- Gastrointestinal malignancies
- Melanoma
Interest also extends to gastrointestinal cancers, pancreatic cancer, hepatocellular carcinoma, and melanoma in advanced or metastatic settings.
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