David G.
- Country
- Spain
- Department
- Cardiology
Research Overview
- A Phase 3, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Levosimendan in Patients with Pulmonary Hypertension and HFpEF
- Phase II Dose-Finding Study of Sublingual Phleum pratense Extract in Adults with Grass Pollen‑Induced Allergic Rhinitis
- Phase III Randomized Double‑Blind Trial of Elecoglipron (AZD5004) on Cardiovascular Mortality and Hospitalization in Adults with HFpEF or HFmrEF on Background Dapagliflozin
Data & Insights
Has run more than one trial at 35 of 310 partner sites.
Specializations
Cardiovascular Medicine
Clinical research in cardiology includes acute coronary syndrome, myocardial infarction, heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, and hypertrophic cardiomyopathy, with interest in therapies for risk reduction, ischemic events, and chronic cardiac dysfunction.
- Acute coronary syndrome
- Heart failure
- Atherosclerotic cardiovascular disease
- Myocardial infarction
- Hypertrophic cardiomyopathy
Research activity also extends to pulmonary arterial hypertension, calcific aortic valve stenosis, recurrent pericarditis, and thromboembolic disease, reflecting a strong therapeutic focus on cardiovascular prevention and advanced cardiac care.
Hematologic Malignancies
The investigator is involved in trials across acute myeloid leukemia, myelodysplastic syndromes, multiple myeloma, lymphoma, and chronic lymphocytic leukemia, with emphasis on relapsed, refractory, and high-risk blood cancers.
- Acute myeloid leukemia
- Multiple myeloma
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
- Myelodysplastic syndromes
Additional work includes mantle cell lymphoma, follicular lymphoma, Waldenström macroglobulinemia, myelofibrosis, and graft-versus-host disease, supporting innovation in targeted and immune-based hematology therapies.
Solid Tumors and Precision Oncology
Oncology research spans breast cancer, lung cancer, colorectal cancer, ovarian cancer, urothelial carcinoma, prostate cancer, and gastrointestinal malignancies, with a strong presence in advanced and metastatic disease.
- Breast cancer
- Non-small cell lung cancer
- Colorectal cancer
- Urothelial carcinoma
- Prostate cancer
Therapeutic interests include HER2-positive, hormone receptor-positive, and triple-negative breast cancer, as well as renal cell carcinoma, hepatocellular carcinoma, and pancreatic cancer, highlighting precision approaches in solid tumor treatment.
Autoimmune and Inflammatory Diseases
Clinical studies include systemic lupus erythematosus, rheumatoid arthritis, juvenile idiopathic arthritis, myasthenia gravis, thyroid eye disease, and Sjögren’s disease, with a therapeutic focus on immune-mediated disorders.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Myasthenia gravis
- Thyroid eye disease
- Juvenile idiopathic arthritis
Related activity also covers psoriasis, bullous pemphigoid, vasculitis, systemic sclerosis, and inflammatory myopathies, indicating involvement in therapies for chronic autoimmune and inflammatory conditions.
Metabolic, Neurologic, and Liver Disorders
The investigator also participates in research on Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, obesity, type 2 diabetes, and non-alcoholic steatohepatitis, reflecting a broad interest in chronic multisystem disease management.
- Alzheimer’s disease
- Multiple sclerosis
- Parkinson’s disease
- Obesity
- Non-alcoholic steatohepatitis
Other areas include chronic liver disease, hepatic encephalopathy, chronic kidney disease, amyloidosis, and pulmonary fibrosis, underscoring engagement with therapies for complex systemic and degenerative disorders.
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