David B.
- Country
- Italy
- Department
- UOC Malattie dell’Apparato Respiratorio
Research Overview
- Efficacy of Belumosudil Mesilate and Anhydrous Azithromycin in Chronic Lung Allograft Dysfunction Post-Bilateral Lung Transplantation
- A Two-Cohort, Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study Evaluating the Efficacy and Safety of Vixarelimab Compared with Placebo in Patients with Idiopathic Pulmonary Fibrosis and in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease
- Evaluation of Immune Response and Safety of RSVPreF3 OA Vaccine in Lung and Renal Transplant Recipients and Healthy Controls
Data & Insights
Has run more than one trial at 17 of 69 partner sites.
Specializations
Thoracic Oncology
Clinical research activity includes non-small cell lung cancer, small cell lung cancer, and other advanced thoracic malignancies, with interest in treatment-resistant disease, molecularly defined subgroups, and resectable or metastatic settings.
- Non-small cell lung cancer
- Small cell lung cancer
- EGFR exon 20 insertion-mutated disease
- KRAS G12C-mutant disease
The therapeutic focus extends to advanced and recurrent lung cancer, including biomarker-driven approaches and combination strategies in oncology.
Melanoma and Skin Cancer
Research involvement centers on melanoma across resected, unresectable, metastatic, and brain-involved disease, together with cutaneous squamous cell carcinoma, basal cell carcinoma, and other skin malignancies.
- Advanced melanoma
- Metastatic melanoma
- Cutaneous squamous cell carcinoma
- Merkel cell carcinoma
Areas of interest also include adjuvant treatment, checkpoint-inhibitor-refractory disease, and intratumoral approaches for difficult-to-treat cutaneous tumors.
Hematologic Malignancies
Clinical trial activity covers a broad spectrum of blood cancers, including acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphoma, and multiple myeloma.
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Multiple myeloma
Therapeutic interests include relapsed or refractory disease, biomarker-defined leukemia, and immune-based or targeted strategies in aggressive hematologic cancers.
Respiratory and Interstitial Lung Disease
As part of the respiratory medicine department, the investigator is engaged in studies of idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, pulmonary sarcoidosis, and chronic lung allograft dysfunction.
- Idiopathic pulmonary fibrosis
- Progressive pulmonary fibrosis
- Pulmonary sarcoidosis
- Chronic lung allograft dysfunction
Research also includes severe asthma and other fibrotic or inflammatory respiratory disorders requiring targeted pulmonary therapy.
Immune-Mediated and Cardiometabolic Disease
Additional research interests include psoriasis, atopic dermatitis, systemic sclerosis-associated interstitial lung disease, cardiovascular disease, type 2 diabetes, and stroke prevention.
- Psoriasis
- Atopic dermatitis
- Cardiovascular disease
- Type 2 diabetes
The portfolio also includes inflammatory, autoimmune, and metabolic conditions linked to chronic organ damage and long-term risk reduction.
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