Dario Francesco D.
- Country
- Italy
- Department
- Dermatology Unit
Research Overview
- Phase 3 Study on the Safety and Efficacy of Upadacitinib Versus Dupilumab in Pediatric Patients Aged 2-12 with Moderate to Severe Atopic Dermatitis
- Phase 3 Multicenter Evaluation of Tralokinumab with Topical Corticosteroids in Pediatric Moderate-to-Severe Atopic Dermatitis
- Efficacy and Safety Evaluation of Ruxolitinib Cream in Pediatric Patients Aged 6 to <12 Years with Nonsegmental Vitiligo: A Phase 3 Randomized, Double-Blind Study
Data & Insights
Has run more than one trial at 31 of 120 partner sites.
Specializations
Pediatric dermatology and inflammatory skin disease
Clinical activity in dermatology includes treatment-focused research in atopic dermatitis, vitiligo, epidermolysis bullosa, Netherton syndrome, and other genetic skin disorders affecting children and adolescents.
- Atopic dermatitis
- Epidermolysis bullosa
- Vitiligo
- Netherton syndrome
Interest also extends to pruritic cholestatic disease and immune-mediated cutaneous inflammation, with a clear emphasis on pediatric therapeutic options.
Inflammatory bowel disease and gastroenterology
The investigator is involved in research on ulcerative colitis, Crohn’s disease, pouchitis, and broader inflammatory bowel diseases in pediatric populations.
- Ulcerative colitis
- Crohn’s disease
- Active chronic pouchitis
- Inflammatory bowel diseases
Therapeutic interests include advanced biologic and immune-modulating strategies for chronic intestinal inflammation.
Pediatric oncology and hematologic malignancies
Research activity covers a wide spectrum of leukemias, lymphomas, and solid tumors, with particular attention to aggressive and relapsed pediatric cancers.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Hodgkin lymphoma
- Neuroblastoma
Additional interests include relapsed or refractory disease, high-risk sarcomas, and targeted immunotherapy for pediatric cancer care.
Autoimmune, rheumatologic, and immune-mediated disorders
The investigator is active in trials for juvenile idiopathic arthritis, systemic lupus erythematosus, Behçet’s disease, myasthenia gravis, and related inflammatory conditions.
- Juvenile idiopathic arthritis
- Systemic lupus erythematosus
- Behçet’s disease
- Generalized myasthenia gravis
Work also includes macrophage activation syndrome and other systemic autoimmune diseases requiring pediatric therapeutic innovation.
Rare genetic, neurologic, and metabolic diseases
Clinical interests span epileptic encephalopathies, tuberous sclerosis complex, spinal muscular atrophy, migraine, and selected metabolic and hereditary disorders.
- Developmental and epileptic encephalopathies
- Tuberous sclerosis complex
- Spinal muscular atrophy
- Friedreich ataxia
Research also includes genetic growth disorders, complement-mediated kidney disease, and other rare pediatric conditions with unmet therapeutic need.
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