Daniele U.
- Country
- Italy
- Department
- U.O.C. Malattie Neurodegenerative
Research Overview
- Phase 2/3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of EXV-802 and EXV-801 in Participants with Agitation in Alzheimer’s Disease
- Efficacy and Safety Evaluation of Lecanemab in Early Alzheimer's Disease: A Placebo-Controlled, Double-Blind, Parallel-Group Study with Open-Label Extension
- Efficacy and Safety Evaluation of ACP-204 Tartrate in Adults with Alzheimer's Disease Psychosis: A Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 91 of 239 partner sites.
Specializations
Neurodegenerative Disease and Dementia
Clinical research activity includes Alzheimer’s disease, mild cognitive impairment due to Alzheimer’s disease, frontotemporal dementia, and Lewy body dementia, with attention to cognitive decline and neuropsychiatric symptoms.
- Early Alzheimer’s disease
- Frontotemporal dementia
- Lewy body dementia psychosis
- Psychosis associated with Alzheimer’s disease
There is also involvement in trials addressing amyloid-targeted therapy and broader symptom control in progressive cognitive disorders.
Neuropsychiatric and Motor Neurology
The investigator is engaged in studies focused on Alzheimer’s disease psychosis, agitation, and autonomic or motor complications in neurological illness, alongside treatment evaluation in amyotrophic lateral sclerosis.
- Alzheimer’s disease psychosis
- Agitation in Alzheimer’s disease dementia
- Amyotrophic lateral sclerosis
- Neurogenic orthostatic hypotension
These activities reflect a therapeutic focus on symptomatic burden, functional impairment, and disease progression in neurologic conditions.
Colorectal Cancer and Gastrointestinal Oncology
Research involvement is extensive in metastatic colorectal cancer, locally advanced rectal cancer, and resectable or molecularly selected colorectal disease, with additional interest in gastric cancer and biliary tract cancer.
- Metastatic colorectal cancer
- Locally advanced rectal cancer
- Gastric or gastroesophageal junction cancer
- Hepatocellular carcinoma
The clinical portfolio also includes biomarker-guided treatment in RAS-, BRAF-, and ctDNA-defined gastrointestinal malignancies.
Hematologic Malignancies and Cellular Therapy
Investigator activity includes lymphoma and leukemia research, particularly in diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, Hodgkin’s lymphoma, and acute myeloid leukemia.
- Diffuse large B-cell lymphoma
- Mantle cell lymphoma
- Follicular lymphoma
- FLT3-mutated acute myeloid leukemia
There is also interest in allogeneic transplantation, autologous stem-cell transplantation, and other advanced treatment strategies for high-risk blood cancers.
Solid Tumors and Targeted Immuno-Oncology
Additional research spans breast cancer, urothelial carcinoma, head and neck squamous cell carcinoma, pancreatic cancer, and renal cell carcinoma, with emphasis on targeted and immune-based treatment options.
- HER2-positive and HER2-low breast cancer
- Urothelial carcinoma
- Head and neck squamous cell carcinoma
- Pancreatic ductal adenocarcinoma
Therapeutic interests also include immunotherapy, antibody-drug conjugates, and precision oncology in advanced solid tumors.
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