Daniela R.
- Country
- Italy
- Department
- U.O. di Pediatria
Research Overview
Data & Insights
Has run more than one trial at 0 of 109 partner sites.
Specializations
Pediatric Hematologic Malignancies
Focused on the treatment and biological understanding of blood‑derived cancers affecting children and adolescents, including Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, and related disorders.
- Risk‑adapted therapy for Acute Lymphoblastic Leukemia
- Targeted approaches in FLT3‑mutated Acute Myeloid Leukemia
- Allogeneic transplantation strategies for high‑risk Myelodysplastic Syndromes
- Maintenance regimens post‑hematopoietic stem cell transplant
Collaboration with national pediatric oncology networks supports multicenter trial enrollment.
Solid Tumor Oncology in Children and Adolescents
Investigation of therapeutic options for malignant solid tumours presenting in the pediatric population, such as FGFR2b‑overexpressing ovarian cancer, Metastatic renal cell carcinoma, and adolescent Colorectal cancer.
- Targeted therapy for FGFR2b‑overexpressing ovarian cancer
- Immunotherapy combinations in Metastatic renal cell carcinoma
- Molecular profiling of Colorectal cancer in adolescents
- Hormone‑driven strategies for Breast cancer subtypes
Integration of pediatric pharmacokinetic data informs dose optimization.
Cardiovascular and Thrombotic Disorders
Research addressing acute and chronic heart disease and cerebrovascular events in young patients, including Acute Myocardial Infarction and Ischemic Stroke.
- Antithrombotic strategies after Acute Ischemic Stroke
- Management of Acute Myocardial Infarction in adolescents
- Risk reduction in Atherosclerotic cardiovascular disease with renal impairment
- Biomarker‑guided therapy for post‑stroke recurrence
Collaboration with cardiology units enhances multidisciplinary care pathways.
Autoimmune and Inflammatory Diseases
Focused on pediatric autoimmune conditions and their therapeutic modulation, such as Juvenile Idiopathic Arthritis and Recurrent pericarditis.
- Early drug withdrawal in Juvenile Idiopathic Arthritis
- Biologic versus conventional DMARD strategies
- Anakinra versus steroids in colchicine‑resistant Recurrent pericarditis
- Safety monitoring of long‑term immunomodulation
Utilization of imaging and multi‑omics for disease activity assessment supports precision treatment.
Renal and Metabolic Disorders
Investigation of kidney disease mechanisms and metabolic complications in children, including IgA nephropathy and pediatric Diabetes mellitus.
- Corticosteroid‑sparing regimens for IgA nephropathy
- SGLT2 inhibitor efficacy in pediatric renal disease
- Metabolic control in Diabetes mellitus with renal involvement
- Biomarker development for progression of chronic kidney disease
Cross‑disciplinary studies with nephrology and endocrinology enhance translational insights.
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