Daniela P.
- Country
- Italy
- Department
- Medicina Interna
Research Overview
- A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Tulisokibart in Participants with Moderately to Severely Active Ulcerative Colitis
- Randomized, Double‑Blind, Placebo‑Controlled Trial of LY4268989 (Adipic Acid) in Adults with Moderately to Severely Active Ulcerative Colitis
- Phase 3 Randomized Double‑Blind Study Evaluating Efficacy and Safety of JNJ‑78934804 Combination Therapy versus Guselkumab in Moderately to Severely Active Crohn’s Disease
Data & Insights
Has run more than one trial at 160 of 338 partner sites.
Specializations
Inflammatory Bowel Disease and Gastrointestinal Immunology
Clinical activity in gastroenterology includes treatment-focused research in ulcerative colitis, Crohn's disease, and other intestinal inflammatory disorders, with attention to mucosal inflammation and symptom control.
- Ulcerative colitis
- Crohn's disease
- Eosinophilic gastritis
- Clostridioides difficile infection
Interest also extends to immune-mediated gastrointestinal disease and recurrence prevention in infection-related bowel conditions.
Digestive Oncology
Research involvement spans colorectal cancer, rectal cancer, and colon cancer, alongside broader work in advanced gastrointestinal malignancies and biomarker-informed treatment selection.
- Metastatic colorectal cancer
- Locally advanced rectal cancer
- Stage III colon cancer
- Advanced solid tumors
Therapeutic interests include targeted therapy, adjuvant treatment, and circulating tumor DNA-guided management in colorectal disease.
Breast Cancer and Hormone-Driven Malignancies
The investigator is active in breast cancer research across early and advanced settings, including HER2-negative disease, triple negative breast cancer, and hormone receptor-positive tumors.
- Early breast cancer
- Advanced/metastatic breast cancer
- Triple negative breast cancer
- HR-positive, HER2-negative breast cancer
Key therapeutic areas include endocrine therapy, CDK4/6 inhibition, and neoadjuvant and adjuvant strategies.
Thoracic Oncology and Solid Tumor Therapy
Clinical trial involvement covers non-small cell lung cancer, small cell lung cancer, and other advanced solid tumors, with interest in treatment sequencing and combination approaches in resistant disease.
- Non-small cell lung cancer
- Extensive-stage small cell lung cancer
- Head and neck squamous cell carcinoma
- Unresectable or metastatic melanoma
Research also includes immune checkpoint-based treatment, antibody-drug conjugates, and other novel oncology agents.
Cardiometabolic, Neurodegenerative, and Respiratory Disorders
The investigator’s portfolio also includes type 2 diabetes, cardiovascular disease, amyloid cardiomyopathy, and Alzheimer's disease, together with asthma and selected ophthalmic disease.
- Type 2 diabetes mellitus
- Acute myocardial infarction
- Transthyretin amyloid cardiomyopathy
- Early symptomatic Alzheimer’s disease
Additional interest is seen in asthma, chronic kidney disease, and neovascular age-related macular degeneration.
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