Daniela A.
- Country
- Portugal
- Department
- Serviço de Hematologia e Transplantação de Medula
Research Overview
- Phase 3 Randomized Study of Nemtabrutinib Versus Investigator’s Choice of Ibrutinib or Acalabrutinib in Untreated CLL/SLL
- Phase 3 Randomized Study of Pirtobrutinib vs. Bendamustine and Rituximab in Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
- Phase 3 Study of Acalabrutinib with R-CHOP in Patients Aged ≤75 with Untreated Non-Germinal Center Diffuse Large B-Cell Lymphoma
Data & Insights
Has run more than one trial at 128 of 298 partner sites.
Specializations
Hematologic Malignancies and Cellular Therapy
Clinical research activity includes acute myeloid leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, multiple myeloma, myelofibrosis, and chronic graft-versus-host disease, with interest in CAR T-cell therapy and other immune-based oncology approaches.
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
- CAR T-cell therapy
Research also extends to bladder cancer, breast cancer, lung cancer, head and neck squamous cell carcinoma, colorectal cancer, and ovarian cancer, reflecting broad involvement in oncology innovation.
Autoimmune, Inflammatory, and Rheumatologic Diseases
Areas of interest include systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, systemic sclerosis, Sjögren’s disease, idiopathic inflammatory myopathies, and polymyalgia rheumatica.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Sjögren’s disease
- Systemic sclerosis
Additional activity covers inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, as well as hidradenitis suppurativa, psoriasis, and prurigo nodularis.
Cardiovascular, Thrombotic, and Renal Medicine
Clinical trial involvement spans atrial fibrillation, atherosclerotic cardiovascular disease, heart failure, acute myocardial infarction, ischemic stroke, and aortic stenosis, with attention to stroke prevention and anticoagulation reversal.
- Atrial fibrillation
- Heart failure
- Ischemic stroke
- Anticoagulation reversal
Research interests also include chronic kidney disease, focal segmental glomerulosclerosis, IgA nephropathy, delayed graft function, and cardiac surgery-associated acute kidney injury.
Neurology, Neurodegeneration, and Rare Genetic Disorders
Investigational work includes multiple sclerosis, myasthenia gravis, epileptic encephalopathies, focal seizures, primary generalized tonic-clonic seizures, and migraine, alongside Parkinson’s disease, Alzheimer’s disease, frontotemporal dementia, and Huntington’s disease.
- Multiple sclerosis
- Myasthenia gravis
- Migraine
- Alzheimer’s disease
Rare disease interests further include spinal muscular atrophy, spinocerebellar ataxia type 3, Wilson disease, Fabry-related and transthyretin amyloidosis, and selected developmental epileptic encephalopathies.
Pulmonary, Metabolic, and Endocrine Disorders
Research activity also covers asthma, chronic obstructive pulmonary disease, bronchiectasis, pulmonary arterial hypertension, interstitial lung disease, and idiopathic pulmonary fibrosis, with additional focus on nontuberculous mycobacterial lung infection.
- Asthma
- Pulmonary arterial hypertension
- Chronic obstructive pulmonary disease
- Bronchiectasis
Metabolic and endocrine interests include metabolic dysfunction-associated steatotic liver disease, non-alcoholic steatohepatitis, obesity, type 2 diabetes, hypercholesterolemia, and hereditary angioedema.
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