Daniel K.
- Country
- Denmark
- Department
- Afdeling for Hjerne- og Nervesygdomme
Research Overview
- Effect of Methylphenidate on the Time to Awakening in Patients with Coma Due to Acute Brain Injury: A Randomized, Double-Blind, Placebo-Controlled Trial
- Evaluation of Psilocybin and Apomorphine Hydrochloride Hemihydrate in Enhancing Consciousness in Comatose Patients with Acute Brain Injury
- Dose Escalation Study of Apomorphine Hydrochloride Hemihydrate and Psilocybin in Comatose Patients with Acute Brain Injury
Data & Insights
Has run more than one trial at 3 of 6 partner sites.
Specializations
Neuroimmunology and Inflammatory Neurological Disease
Clinical research interest includes multiple sclerosis, progressive multiple sclerosis, relapsing-remitting multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, and autoimmune neurological disorders. The investigator is also involved in studies of trigeminal neuralgia, migraine, status epilepticus, and idiopathic intracranial hypertension.
- Multiple sclerosis and demyelinating disease
- Myasthenia gravis and peripheral neuropathy
- Headache disorders and neuroinflammatory pain
Work in this area also extends to neurodegenerative disease and cognitive impairment, including Alzheimer’s disease and related clinical syndromes.
Stroke, Neurocritical Care, and Acute Brain Injury
Research activity includes ischemic stroke, acute ischemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, traumatic brain injury, and coma or other disorders of consciousness after acute brain injury. The investigator is also linked to studies in cardiac arrest and cerebral ischemia prevention.
- Acute stroke and transient ischemic attack
- Brain hemorrhage and traumatic brain injury
- Disorders of consciousness and neuroresuscitation
Therapeutic interests include strategies for secondary stroke prevention and management of severe neurological complications in urgent care settings.
Cardiovascular Medicine and Thromboembolic Disease
Clinical trial involvement spans myocardial infarction, coronary artery bypass grafting, atrial fibrillation, heart failure, cardiogenic shock, pulmonary embolism, and atherosclerotic cardiovascular disease. The investigator also participates in research on pulmonary arterial hypertension and vascular disease.
- Acute coronary syndromes and post-cardiac surgery care
- Heart failure and arrhythmia
- Pulmonary embolism and pulmonary vascular disease
Areas of therapeutic interest also include antithrombotic treatment, cardiometabolic risk, and intervention strategies for unstable cardiovascular conditions.
Neuro-oncology, Haematologic Malignancies, and Pediatric Cancer
The investigator is active in trials covering glioblastoma, glioma, medulloblastoma, diffuse midline glioma, brain tumors, acute lymphoblastic leukemia, acute myeloid leukemia, lymphoma, and multiple myeloma. Research also includes pediatric solid tumors and relapsed or refractory malignancies.
- Central nervous system tumors and brain malignancies
- Leukemia, lymphoma, and myeloma
- Pediatric oncology and relapsed cancer
Therapeutic focus includes targeted oncology, immunotherapy, and treatment approaches for aggressive or recurrent cancers across adult and pediatric populations.
Rare Disease, Autoimmune Medicine, and Organ-Specific Disorders
Additional research interests include cystic fibrosis, primary ciliary dyskinesia, Fabry disease, muscular dystrophy, haemophilia, IgA nephropathy, lupus nephritis, and Sjögren’s disease. The investigator is also involved in studies of asthma, bronchiectasis, chronic kidney disease, and transplant-related metabolic complications.
- Rare genetic and metabolic disease
- Autoimmune renal and systemic disease
- Respiratory and transplant-related disorders
Therapeutic domains also cover inflammatory disease, enzyme-related disorders, and organ preservation in chronic multisystem conditions.
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