Cyrille H.
- Country
- France
- Department
- Hôpital Bretonneau - Service Transversal d’Allergologie et Immunologie Clinique
Research Overview
Data & Insights
Has run more than one trial at 21 of 22 partner sites.
Specializations
Allergic and Asthmatic Disorders
The investigator concentrates on the pathophysiology and clinical management of allergy and related airway diseases, emphasizing precision diagnostics and targeted biologic therapies.
- Severe allergic asthma
- Chronic rhinosinusitis with polyps
- Urticaria and angioedema syndromes
- Food‑triggered anaphylaxis
These efforts aim to reduce exacerbations, improve quality of life, and integrate biomarker‑driven treatment algorithms.
Systemic Autoimmune Diseases
Focused on immune‑mediated systemic conditions, the investigator evaluates novel immunomodulatory strategies to achieve sustained remission.
- Systemic lupus erythematosus (SLE)
- ANCA‑associated vasculitis
- Active psoriatic arthritis
- Juvenile idiopathic arthritis subtypes
Research integrates clinical phenotyping with emerging biologics to tailor therapy and limit organ damage.
Primary Immunodeficiency and Immunotherapy
The clinical program addresses inherited and acquired immune deficiencies, exploring therapeutic antibodies and cellular approaches.
- Hereditary angioedema
- Immunoglobulin replacement in primary immunodeficiency
- Checkpoint inhibition in tumor immunology
- Adoptive T‑cell therapies for viral infections
Objectives include restoring immune competence while minimizing adverse events.
Rare Immunologic and Amyloid Disorders
Specialized interest lies in uncommon conditions where dysregulated protein deposition or autoinflammation drives disease.
- Systemic AL amyloidosis
- VEXAS syndrome
- Autoimmune hemolytic uremic syndrome
- Hereditary transthyretin amyloid cardiomyopathy
Clinical trials evaluate targeted inhibitors and gene‑silencing strategies to halt disease progression.
Immunologic Oncology
Integrating immunology with oncology, the investigator investigates immune‑based interventions for malignancies of the head, neck, and thoracic regions.
- Non‑small cell lung cancer immunotherapy
- Head and neck squamous cell carcinoma checkpoint trials
- Salivary gland carcinomas immune profiling
- Biomarker development for tumor microenvironment
Work focuses on enhancing anti‑tumor immunity and identifying predictive markers for treatment response.
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