Clinical Research
person

Constanza N. M.

Country
Spain
Department
Endocrinology

Research Overview

assignment
1
Clinical Trials ·
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1
Research Sites

Data & Insights

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Primary Speciality
Main therapeutic area

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Return Partnerships
Recurring site collaborations
0
Sites with multiple studies

Has run more than one trial at 0 of 13 partner sites.

Specializations

Hormone‑responsive breast cancer

Focus on malignancies driven by estrogen receptor positive and HER2‑negative pathways, exploring endocrine blockade and targeted combination strategies.

  • Estrogen receptor‑positive, HER2‑negative advanced disease
  • CDK4/6 inhibitor‑based endocrine therapy
  • Adjuvant endocrine treatment in early‑stage disease

Research aims to improve progression‑free outcomes and reduce recurrence risk in hormone‑driven breast cancer.

Metabolic diabetes and obesity

Investigation of therapeutic approaches for type 2 diabetes and related adiposity, targeting glycemic control and weight reduction.

  • GLP‑1 receptor agonist therapy
  • Combination regimens for insulin resistance
  • Obesity‑associated cardiovascular risk mitigation

Efforts emphasize metabolic improvement and prevention of diabetes‑related complications.

Pituitary‑adrenal endocrine disorders

Clinical studies addressing disorders of hormone excess, including acromegaly and Cushing syndrome, with novel medical and surgical adjuncts.

  • Somatostatin analogue therapy for acromegaly
  • Steroidogenesis inhibition in Cushing syndrome
  • Management of adrenal hyperplasia

Objectives target biochemical normalization and symptom relief.

Lipid disorders and atherosclerotic cardiovascular disease

Research on dyslipidemias contributing to atherosclerotic cardiovascular disease, with emphasis on elevated lipoprotein(a) and therapeutic lowering.

  • Lipoprotein(a)‑targeted antisense therapy
  • Statin‑intensive regimens for ASCVD prevention
  • Risk stratification in hyperlipidemic patients

Goal is to reduce major adverse cardiovascular events through lipid modulation.

Rare endocrine genetic syndromes

Study of inherited conditions affecting endocrine signaling, such as Activated Phosphoinositide 3‑Kinase Delta Syndrome and related PI3K pathway mutations.

  • Targeted PI3K inhibition
  • Genotype‑guided therapeutic selection
  • Immune dysregulation management

Efforts aim to translate molecular insights into precision treatments.

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