Coline B. P.
- Country
- France
- Department
- Service de Pédiatrie
Research Overview
Data & Insights
Has run more than one trial at 0 of 2 partner sites.
Specializations
Hormone Receptor‑Positive, HER2‑Negative Breast Cancer
The investigator focuses on estrogen receptor‑positive, HER2‑negative breast cancer across early and metastatic settings.
- BRCA‑mutated disease management
- CDK 4/6 inhibitor combination strategies
- adjuvant endocrine therapy optimization
Research emphasizes targeted therapies and biomarker‑driven treatment adaptation.
HER2‑Positive Breast Cancer
Clinical work addresses HER2‑positive locally advanced or metastatic breast cancer with maintenance and de‑escalation approaches.
- anti‑HER2 targeted therapy duration studies
- ctDNA‑guided treatment decisions
- combined HER2 blockade regimens
Efforts target sustained disease control while reducing treatment burden.
Triple‑Negative Breast Cancer
Investigation includes early triple‑negative breast cancer achieving pathologic complete response and subsequent immunotherapy strategies.
- neoadjuvant chemotherapy plus checkpoint inhibition
- pCR‑guided adjuvant therapy evaluation
- biomarker‑based recurrence risk assessment
Focus is on consolidating response and preventing relapse.
Multiple Myeloma
Research addresses relapsed and newly diagnosed multiple myeloma in frail and transplant‑ineligible populations.
- daratumumab‑lenalidomide fixed‑duration trials
- elranatamab‑lenalidomide consolidation and maintenance
- minimal residual disease driven treatment adaptation
Therapeutic goals include depth of response and durable disease control.
Pediatric Metabolic & Critical Care
The investigator contributes to obese children and adolescents vitamin D supplementation and to severe respiratory infections in intensive care.
- vitamin D repletion dosing strategies
- high‑flow nasal oxygen weaning protocols
- severe community‑acquired bacterial pneumonia adjunctive therapy
- sepsis rapid recognition tools
Work integrates metabolic optimization with acute respiratory support innovations.
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