Cleo D. B.
- Country
- Belgium
- Department
- Centrum voor Oncologie
Research Overview
Data & Insights
Has run more than one trial at 0 of 83 partner sites.
Specializations
Oncology
The investigator concentrates on a broad spectrum of solid‑tumor malignancies, including breast cancer, prostate cancer, endometrial cancer, ovarian cancer, colorectal cancer, pancreatic ductal adenocarcinoma, and gastric cancer.
- Advanced breast cancer
- Metastatic castration‑refractory prostate cancer
- High‑risk endometrial cancer
- HER2‑positive colorectal cancer
- Pancreatic ductal adenocarcinoma
Research emphasizes targeted agents, immunotherapy combinations, and strategies to improve survival in high‑risk patient groups.
Cardiovascular Medicine
Work in this area addresses conditions such as acute coronary syndrome, coronary artery disease, and broader atherosclerotic cardiovascular disease with a focus on elevated lipoprotein(a) levels.
- Secondary prevention after myocardial infarction
- Non‑obstructive coronary artery disease
- Lipoprotein(a)‑lowering strategies
- Antiplatelet therapy optimization
Efforts aim to reduce major adverse cardiovascular events and refine long‑term management of high‑risk cardiovascular patients.
Metabolic & Endocrine Disorders
Investigations include early metabolic derangements such as prediabetes and glucose intolerance following gestational diabetes, as well as weight‑loss challenges linked to cancer‑associated cachexia.
- Prediabetes progression
- Gestational diabetes management
- Weight loss in cancer‑related cachexia
The therapeutic focus is on improving glycemic control and preserving metabolic health in vulnerable populations.
Gastrointestinal & Hepatic Diseases
Key disease interests comprise Crohn's disease, chronic hepatitis B infection, small bowel adenocarcinoma, and molecularly defined gastric cancers such as FGFR2b‑positive gastric cancer.
- Inflammatory bowel disease
- Chronic hepatitis B viral control
- Adjuvant therapy for small bowel adenocarcinoma
- Targeted treatment of FGFR2b‑positive gastric cancer
Research prioritizes biologic and targeted modalities to address disease progression and improve patient outcomes.
Neuro‑Trauma & Reproductive Medicine
Clinical interests extend to acute traumatic brain injury and fertility enhancement techniques, notably the use of tubal flushing to increase live‑birth rates in women with tubal factor infertility.
- Acute traumatic brain injury
- Fertility enhancement with tubal flushing
Goals include optimizing neurological recovery and improving reproductive success in affected patients.
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