Clémence L.
- Country
- France
- Department
- Hôpital Michallon, Hepato-gastroenterology
Research Overview
- Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Duvakitug for Induction Therapy in Moderately to Severely Active Crohn's Disease
- Efficacy and Safety of Duvakitug for Maintenance Therapy in Participants with Moderately to Severely Active Crohn’s Disease: A Phase 3, Randomized, Placebo-Controlled Study
- Comparison of Vedolizumab, Filgotinib, Ustekinumab, and Infliximab as First-Line Advanced Therapy to Maintain Remission in Patients with Ulcerative Colitis
Data & Insights
Has run more than one trial at 192 of 363 partner sites.
Specializations
Hepatology and biliary tract oncology
Clinical research activity includes hepatocellular carcinoma, cholangiocarcinoma, primary biliary cholangitis, primary sclerosing cholangitis, and alcoholic hepatitis, with interest in liver-directed and systemic treatment strategies.
- Hepatocellular carcinoma
- Biliary tract cancer
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Alcoholic hepatitis
Work also extends to pancreatic adenocarcinoma and gastroenteropancreatic neuroendocrine carcinoma, reflecting a strong therapeutic focus on digestive cancers.
Hematologic malignancies and cellular therapy
The investigator is involved in studies of acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndromes, lymphomas, and multiple myeloma, spanning both frontline and relapsed disease settings.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Diffuse large B-cell lymphoma
- Multiple myeloma
Additional interest includes allogeneic hematopoietic stem cell transplantation, graft-versus-host disease, and Richter syndrome.
Thoracic and solid tumor oncology
Research activity covers non-small cell lung cancer, small cell lung cancer, melanoma, breast cancer, renal cell carcinoma, and urothelial carcinoma, with a broad interest in advanced solid tumors.
- Non-small cell lung cancer
- Small cell lung cancer
- Melanoma
- Breast cancer
- Renal cell carcinoma
Therapeutic themes also include head and neck squamous cell carcinoma, ovarian cancer, and pancreatic cancer.
Autoimmune, inflammatory, and renal disease
The investigator participates in trials in rheumatoid arthritis, ulcerative colitis, Crohn’s disease, systemic sclerosis, Sjögren’s syndrome, and vasculitis.
- Rheumatoid arthritis
- Inflammatory bowel disease
- Systemic sclerosis
- Sjögren’s syndrome
- ANCA-associated vasculitis
Renal-focused work includes chronic kidney disease, IgA nephropathy, kidney transplantation, and antibody-mediated rejection.
Respiratory, cardiovascular, and neurologic disorders
Clinical interests also include asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and pulmonary arterial hypertension, alongside cardiovascular studies in atherosclerotic cardiovascular disease, myocardial infarction, and heart failure.
- Asthma
- Chronic obstructive pulmonary disease
- Pulmonary arterial hypertension
- Atherosclerotic cardiovascular disease
- Heart failure
Neurologic and immune-mediated areas include multiple sclerosis, Parkinson’s disease, migraine, and Tourette’s disorder.
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