Chiara Maria E.
- Country
- Italy
- Department
- Oculistica
Research Overview
- Randomized, Double-Masked, Multicenter Phase 2/3 Trial of Intravitreal MK-8748 Versus Aflibercept in Patients with Neovascular Age‑Related Macular Degeneration
- Evaluation of Efficacy and Safety of Intravitreal EYE103 Versus Ranibizumab in Diabetic Macular Edema: A Randomized, Double-Masked, Multi-Center Study
- Efficacy and Safety Evaluation of Intravitreal EYE103 Versus Ranibizumab in Diabetic Macular Edema: A Randomized, Double-Masked, Phase 2/3 Study
Data & Insights
Has run more than one trial at 66 of 111 partner sites.
Specializations
Ocular oncology and retinal disease
Clinical research activity includes ophthalmology with a focus on sight-threatening disorders such as diabetic macular edema, age-related macular degeneration, and glaucoma, alongside ocular involvement in complex neoplastic and inflammatory conditions.
- Diabetic macular edema
- Neovascular age-related macular degeneration
- Open-angle glaucoma
- Ocular adnexal lymphoma
The therapeutic interest extends to preserving visual function through targeted intraocular and systemic approaches for chronic retinal and optic nerve disease.
Hematologic malignancies
The investigator is involved in studies across a broad spectrum of blood cancers, including acute leukemias, lymphomas, multiple myeloma, and myelodysplastic syndromes, with particular attention to relapsed, refractory, and high-risk disease.
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Myelodysplastic syndromes
Research also includes stem cell transplantation-related settings and post-treatment maintenance strategies in hematologic oncology.
Solid tumors and pediatric oncology
Clinical interests cover a wide range of solid tumors, including breast cancer, ovarian cancer, melanoma, prostate cancer, and gastrointestinal malignancies, as well as childhood cancers requiring disease-specific treatment development.
- Breast cancer
- Ovarian cancer
- Melanoma
- Neuroblastoma
Therapeutic activity also includes pediatric solid tumors and rare embryonal tumors, reflecting involvement in oncology across age groups.
Immune-mediated and inflammatory diseases
Research spans autoimmune and inflammatory disorders affecting the skin, joints, gut, and nervous system, including hidradenitis suppurativa, inflammatory bowel disease, psoriasis, and myasthenia gravis.
- Hidradenitis suppurativa
- Crohn’s disease
- Ulcerative colitis
- Generalized myasthenia gravis
This area also includes immune thrombocytopenia, graft-versus-host disease, and other immune dysregulation syndromes.
Cardiometabolic, renal, and liver disease
The investigator’s portfolio includes cardiovascular disease, heart failure, atrial fibrillation, hypertension, kidney disease, and metabolic liver disease, with attention to chronic conditions requiring long-term therapeutic management.
- Heart failure
- Chronic kidney disease
- Metabolic dysfunction-associated steatohepatitis
- Atherosclerotic cardiovascular disease
Research activity also covers thromboembolic disorders, proteinuric kidney disease, and other systemic metabolic complications.
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